对甲苯磺酰胺

对甲苯磺酰胺用途

【用途一】
用于制造增塑剂、消毒剂,也可用于生产合成树脂、涂料、萤光染料等。
【用途二】
用于制造染料、增塑剂、合成树脂、涂料、消毒剂及木材加工光亮剂等
【用途三】
用作增塑剂，也用于有机物、树脂和糖精的合成
【用途四】
在光亮镀镍中作初级光亮剂。用于光亮多层镀镍，使镀层光亮均匀。一般用量0.2～0.3 g/L。
【用途五】
用于制造染料、增塑剂、树脂、涂料、消毒剂（氯胺T）、木材加工光亮剂等。
【用途六】
有机合成、增塑剂、树脂和涂料的防霉杀菌剂。

对甲苯磺酰胺名称

[ CAS 号 ]:
70-55-3

[ 中文名 ]:
对甲苯磺酰胺

[ 英文名 ]:
4-Toluenesulfonamide

[中文别名 ]:

[英文别名 ]:

4-Methylbenzenesulfonamide
4-Toluenesulfonamide
p-Toluenesulfonamide
MFCD00011692
ZSWR D1
EINECS 200-741-1
p-Tosylamide

对甲苯磺酰胺生物活性

[ 描述 ]:

对甲苯磺酰胺是一种生物化学试剂,可作为生物材料或有机化合物进行生命科学相关研究。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

对甲苯磺酰胺物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
322.2±35.0 °C at 760 mmHg

[ 熔点 ]:
134-137 °C(lit.)

[ 分子式 ]:
C₇H₉NO₂S

[ 分子量 ]:
171.22

[ 闪点 ]:
148.6±25.9 °C

[ 精确质量 ]:
171.035400

[ PSA ]:
68.54000

[ LogP ]:
0.79

[ 外观性状 ]:
白色结晶粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.564

[ 储存条件 ]:
室温

[ 水溶解性 ]:
0.32 g/100 mL (25 º C)

对甲苯磺酰胺MSDS

详细MSDS(安全技术说明书)

对甲苯磺酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XT5075000

CHEMICAL NAME :: p-Toluenesulfonamide

CAS REGISTRY NUMBER :: 70-55-3

BEILSTEIN REFERENCE NO. :: 0472689

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C7-H9-N-O2-S

MOLECULAR WEIGHT :: 171.23

WISWESSER LINE NOTATION :: ZSWR D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - muscle weakness

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :: Insect - Drosophila melanogaster

DOSE/DURATION :: 2500 umol/plate

REFERENCE :: 45OHAA "Short-Term Test Systems for Detecting Carcinogens, Proceedings of the Symposium, 1978," Norpoth, K.H., and R.G. Garner, eds., Berlin, Springer-Verlag, 1980 Volume(issue)/page/year: -,170,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1329 No. of Facilities: 195 (estimated) No. of Industries: 5 No. of Occupations: 29 No. of Employees: 4613 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - A1329 No. of Facilities: 304 (estimated) No. of Industries: 8 No. of Occupations: 16 No. of Employees: 9023 (estimated) No. of Female Employees: 1223 (estimated)

对甲苯磺酰胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
XT5075000

[ 包装等级 ]:
III

[ 海关编码 ]:
2935009090

对甲苯磺酰胺合成路线

详细合成路线

对甲苯磺酰胺上下游产品

对甲苯磺酰胺上游产品

对甲苯磺酰胺下游产品

对甲苯磺酰胺制备

【方法一】
首先将部分HN₃水加入反应锅内，搅拌下加入对甲苯磺酰氯，温度自然升至50 ℃以上，待温度下降后再加入剩余的氨水。于85～90 ℃反应0.5 h。至pH值为8～9时结束反应。冷至20 ℃，过滤，滤饼用水洗，得粗品。再经活性碳脱色，碱溶，酸析，甩滤，干燥得产品。
【方法二】
由对甲苯磺酰氯与氨水反应而得。

对甲苯磺酰胺海关

[ 海关编码 ]: 2935009090

[ 中文概述 ]:
2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:35.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

对甲苯磺酰胺文献

Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.

Bioorg. Med. Chem. Lett. 21 , 710-4, (2011)

The catalytic activity and the inhibition of a new coral carbonic anhydrase (CA, EC 4.2.1.1), from the scleractinian coral Stylophora pistillata, STPCA-2, has been investigated. STPCA-2 has high catal...

Identifying chelators for metalloprotein inhibitors using a fragment-based approach.

J. Med. Chem. 54 , 591-602, (2011)

Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced...

Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.

Bioorg. Med. Chem. 20 , 1403-10, (2012)

The α-carbonic anhydrase (CA, EC 4.2.1.1) Astrosclerin-3 previously isolated from the living fossil sponge Astrosclera willeyana (Jackson et al., Science 2007, 316, 1893), was cloned, kinetically char...

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