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磺溴酚酞钠盐水合物

磺溴酚酞钠盐水合物用途

Sulfobromophthalein (Bromosulfophthalein) disodium salt 是一种有机阴离子染料,用于研究动物组织中表达的各种莫再提,并参与药物和代谢物的运输。

磺溴酚酞钠盐水合物名称

[ CAS 号 ]:
71-67-0

[ 中文名 ]:
四溴磺酚钠

[ 英文名 ]:
Sulfobromophthalein disodium salt

[英文别名 ]:

EINECS 200-761-0
MFCD00150017
Bromosulphthalein
Bromsulphalein
Bromsulfalein
Hepatosulfalein
Sodium bromsulphalein
Sodium bromosulfophthalein
Bromosulfophthalein
Sulfobromophthalein

磺溴酚酞钠盐水合物生物活性

[ 描述 ]:

Sulfobromophthalein (Bromosulfophthalein) disodium salt 是一种有机阴离子染料,用于研究动物组织中表达的各种莫再提,并参与药物和代谢物的运输。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 代谢疾病

[体外研究]

磺基溴酞二钠盐是一种合成染料,于1925年作为临床工具引入,旨在评估肝功能[1]。磺基溴酞(BSP)是一种pH指示剂染料,具有快速(17)的、原独立的喹啉-酚互变异构(pK=8.5)[1]。溴代磺酸盐通常被用作有机阴离子转运多肽1B1(OATP1B1)、OATP1B3、OATP1A2和OATP2B1以及多药耐药蛋白2(MDR2)的底物和抑制剂[2]。

[参考文献]

[1]. Saki Izumi, et al. Substrate-dependent inhibition of organic anion transporting polypeptide 1B1: comparative analysis with prototypical probe substrates estradiol-17β-glucuronide, estrone-3-sulfate, and sulfobromophthalein. Drug Metab Dispos. 2013 Oct;41(10):1859-66.

磺溴酚酞钠盐水合物物理化学性质

[ 分子式 ]:
C₂₀H₈Br₄Na₂O₁₀S₂

[ 分子量 ]:
837.99700

[ 精确质量 ]:
833.60900

[ PSA ]:
205.76000

[ LogP ]:
6.57600

[ 外观性状 ]:
白色结晶固体

[ 储存条件 ]:
室温，密闭，干燥

磺溴酚酞钠盐水合物MSDS

详细MSDS(安全技术说明书)

磺溴酚酞钠盐水合物毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SM8395000

CHEMICAL NAME :: Phenolphthalein, 4,5,6,7-tetrabromo-3',3''-disulfo-, disodium salt

CAS REGISTRY NUMBER :: 71-67-0

LAST UPDATED :: 199712

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C20-H8-Br4-O10-S2.2Na

MOLECULAR WEIGHT :: 838.02

WISWESSER LINE NOTATION :: T56 BVO DHJ DR DQ CSWO& DR DQ CSWO& FE GE HE IE &-NA- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 334 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,394,1982

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 24,265,1925

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 24,265,1925 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6097 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 628 (estimated) No. of Female Employees: 314 (estimated)

磺溴酚酞钠盐水合物安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R42/43

[ 安全声明 (欧洲) ]:
S24/25

[ WGK德国 ]:
3

[ RTECS号 ]:
SM8395000

磺溴酚酞钠盐水合物制备

将四溴邻苯二甲酸酐与苯酚缩合后，再磺化，制成钠盐即得。