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4-硝基苯-α-D-吡喃半乳糖苷

4-硝基苯-α-D-吡喃半乳糖苷用途

【用途一】
α-D-半乳糖苷酶（α-D-Galactosidase）的底物。结合到大肠杆菌乳糖蛋白载体上。

4-硝基苯-α-D-吡喃半乳糖苷名称

[ CAS 号 ]:
7493-95-0

[ 中文名 ]:
4-硝基苯基-α-D-吡喃半乳糖苷

[ 英文名 ]:
4-Nitrophenyl α-D-galactopyranoside

[中文别名 ]:

[英文别名 ]:

4-nitrophenyl-alpha-D-galactoside
4-Nitrophenyl β-D-galactopyranoside
1-O-[P-NITROPHENYL]-β-D-GALACTOPYRANOSE
β-D-Galactopyranoside, 4-nitrophenyl (9CI)
β-D-Galactopyranoside, 4-nitrophenyl
MFCD00065050
p-Nitrophenyl .α.-D-galactopyranoside
α-D-Galactopyranoside, 4-nitrophenyl
p-Nitrophenyl α-D-galactopyranoside
4-Nitrophenyl α-D-galactopyranoside

4-硝基苯-α-D-吡喃半乳糖苷生物活性

[ 描述 ]:

4-Nitrophenyl α-D-galactopyranoside (PNP-alpha-D-Gal) 是一种 4-硝基苯基 (pNP) 糖吡喃糖苷的人工底物,用于检测 α-半乳糖苷酶活性。当 4-Nitrophenyl α-D-galactopyranoside 用作底物时,释放的 pNP 量会显着增加。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[体外研究]

以4-硝基苯酚(pNP)-吡喃糖苷为假底物,在pH 4.0时,4-硝基苯基α-D-半乳吡喃糖苷的pNP释放量显著高于其他pNP-吡喃糖苷,而在pH 7.0时没有检测到活性[1]。以4-硝基苯基(pNP)吡喃糖甙为人工底物的消化试验表明,yieldin从4-硝基苯基α-D-半乳吡喃糖甙中释放半乳糖残基的主要条件是pH值为4.0,也就是产额阈值最多降低的pH值[1]。

[参考文献]

[1]. Okamoto-Nakazato A. Implications of the galactosidase activity of yieldin in the regulatory mechanism of yield threshold that is fundamental to cell wall extension. Physiol Plant. 2018 Jun;163(2):259-266.

4-硝基苯-α-D-吡喃半乳糖苷物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
582.2±50.0 °C at 760 mmHg

[ 熔点 ]:
166-169ºC

[ 分子式 ]:
C₁₂H₁₅NO₈

[ 分子量 ]:
301.249

[ 闪点 ]:
305.9±30.1 °C

[ 精确质量 ]:
301.079773

[ PSA ]:
145.20000

[ LogP ]:
-0.55

[ 外观性状 ]:
固体;White to Orange to Green powder to crystal

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.648

[ 储存条件 ]:
2-8°C

4-硝基苯-α-D-吡喃半乳糖苷MSDS

4-硝基苯-α-D-吡喃半乳糖苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

4-硝基苯-α-D-吡喃半乳糖苷合成路线

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4-硝基苯-α-D-吡喃半乳糖苷文献

The galactophilic lectin, LecA, contributes to biofilm development in Pseudomonas aeruginosa.

Environ. Microbiol. 8(6) , 1095-104, (2006)

LecA (PA-IL) is a cytotoxic lectin and adhesin produced by Pseudomonas aeruginosa which binds hydrophobic galactosides with high specificity and affinity. By using a lecA-egfp translation fusion and i...

Cryptosporidium p30, a galactose/N-acetylgalactosamine-specific lectin, mediates infection in vitro.

J. Biol. Chem. 282 , 34877-87, (2007)

Cryptosporidium sp. cause human and animal diarrheal disease worldwide. The molecular mechanisms underlying Cryptosporidium attachment to, and invasion of, host cells are poorly understood. Previously...

Binding of hydrophobic D-galactopyranosides to the lactose permease of Escherichia coli.

Biochemistry 41(43) , 13039-45, (2002)

Binding of alpha- and beta-D-galactopyranosides with different hydrophobic aglycons was compared using substrate protection against N-ethylmaleimide alkylation of single-Cys148 lactose permease. As de...

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