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OR-486,COMT抑制剂

OR-486,COMT抑制剂用途

3,5-二硝基邻苯二酚(OR-486)是一种有效的邻苯二酚-O-甲基转移酶抑制剂,IC50为12 nM。3,5-二硝基邻苯二酚可用于制备钼(VI)-3,5-二硝基邻苯二酚络合物[1][2][3]。

OR-486,COMT抑制剂名称

[ CAS 号 ]:
7659-29-2

[ 中文名 ]:
3,5-二硝兒茶酚

[ 英文名 ]:
OR-486

[中文别名 ]:

3,5-二硝茶酚

[英文别名 ]:

3,5-Dinitropyrocatechol
4,6-dinitro-o-cresol
Pyrocatechol,3,5-dinitro
MFCD00069263
3,5-dinitrocatechol
3,5-Dinitro-1,2-benzenediol
1,2-Benzenediol,3,5-dinitro
OR-486

OR-486,COMT抑制剂生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

[参考文献]

[1]. Nissinen E, et, al. Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat. Eur J Pharmacol. 1988 Aug 24;153(2-3):263-9.

[2]. Yamaki F, et, al. Effects of Catecholamine Metabolites on Beta-Adrenoceptor-Mediated Relaxation of Smooth Muscle: Evaluation in Mouse and Guinea-Pig Trachea and Rat Aorta. Biol Pharm Bull. 2020;43(3):493-502.

[3]. Stojnova K, et, al. Study on the Complex Equilibria of Molybdenum(VI) with 3,5-Dinitrocatechol and Ditetrazolium Salt. Acta Chim Slov. 2016;63(3):654-60.

OR-486,COMT抑制剂物理化学性质

[ 密度 ]:
1.819g/cm3

[ 沸点 ]:
354.5ºC at 760 mmHg

[ 分子式 ]:
C₆H₄N₂O₆

[ 分子量 ]:
200.10600

[ 闪点 ]:
162.2ºC

[ 精确质量 ]:
200.00700

[ PSA ]:
132.10000

[ LogP ]:
1.96060

[ 折射率 ]:
1.712

[ 储存条件 ]:
2-8°C，避光

OR-486,COMT抑制剂毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ8947010

CHEMICAL NAME :: 1,2-Benzenediol, 3,5-dinitro-

CAS REGISTRY NUMBER :: 7659-29-2

BEILSTEIN REFERENCE NO. :: 2217246

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C6-H4-N2-O6

MOLECULAR WEIGHT :: 200.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 72,952,1989

OR-486,COMT抑制剂安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
CZ8947010

OR-486,COMT抑制剂合成路线

详细合成路线

OR-486,COMT抑制剂上下游产品

OR-486,COMT抑制剂上游产品

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OR-486,COMT抑制剂文献

UWA-121, a mixed dopamine and serotonin re-uptake inhibitor, enhances L-DOPA anti-parkinsonian action without worsening dyskinesia or psychosis-like behaviours in the MPTP-lesioned common marmoset.

Neuropharmacology 82 , 76-87, (2014)

L-3,4-Dihydroxyphenylalanine (L-DOPA) is the most effective treatment for Parkinson's disease (PD), but its long-term administration is complicated by wearing-off and dyskinesia. UWA-101, a dual, equi...

Oxidative deamination of noradrenaline in human blood vessels.

J. Neural Transm. Suppl. 32 , 395-404, (1990)

Human vascular tissue (saphenous vein and uterine artery) was incubated with tritiated noradrenaline. In both vessels, oxidative deamination predominated over O-methylation. Deamination was due to the...

(−)-Epicatechin in the prevention of tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity

Arch. Biochem. Biophys. 573 , 84-91, (2015)

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