Ritipenemacoxil
Ritipenemacoxil名称
[ CAS 号 ]:
87238-52-6
[ 英文名 ]:
Ritipenemacoxil
[英文别名 ]:
- Ritanserinum [Latin]
- Ritanserine
- Ritanserinum
- Ritanserine [French]
- ritanserin
- Ritanserina
- risperidone
- Tiserton
- Ritanserina [Spanish]
Ritipenemacoxil物理化学性质
[ 密度 ]:
1.57g/cm3
[ 沸点 ]:
656ºC at 760 mmHg
[ 分子式 ]:
C13H16N2O8S
[ 分子量 ]:
360.34000
[ 闪点 ]:
350.6ºC
[ 精确质量 ]:
360.06300
[ PSA ]:
171.75000
[ 折射率 ]:
1.62
Ritipenemacoxil毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XI0192000
- CHEMICAL NAME :
- 4-Thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-6- (1-hydroxyethyl)-7-oxo-, (acetyloxy)methyl ester, (5R-(5-alpha,6-alpha(R*)))-
- CAS REGISTRY NUMBER :
- 87238-52-6
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C13-H16-N2-O8-S
- MOLECULAR WEIGHT :
- 360.37
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- JACHDX Journal of Antimicrobial Chemotherapy. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1975- Volume(issue)/page/year: 23(Suppl C),129,1989
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4363 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- JACHDX Journal of Antimicrobial Chemotherapy. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1975- Volume(issue)/page/year: 23(Suppl C),129,1989 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 91 gm/kg/26W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - urine volume decreased Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Metabolism (Intermediary) - lipids including transport
- REFERENCE :
- TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 23,34,1995
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 42 gm/kg/2W-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- REFERENCE :
- JACHDX Journal of Antimicrobial Chemotherapy. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1975- Volume(issue)/page/year: 23(Suppl C),129,1989
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 73 gm/kg/26W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes Kidney, Ureter, Bladder - changes in bladder weight
- REFERENCE :
- TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 23,34,1995
Ritipenemacoxil合成路线
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