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卵泡刺激素

卵泡刺激素用途

促卵泡激素是一种异二聚体糖蛋白,由垂体前叶的促性腺激素表达。卵泡刺激激素影响动物的生育能力和生殖效率[1][2]。

卵泡刺激素名称

[ CAS 号 ]:
9002-68-0

[ 中文名 ]:
卵泡刺激素

[ 英文名 ]:
Follicle-stimulating hormone

[英文别名 ]:

EINECS 232-662-3
MFCD00131099

卵泡刺激素生物活性

[ 描述 ]:

促卵泡激素是一种异二聚体糖蛋白,由垂体前叶的促性腺激素表达。卵泡刺激激素影响动物的生育能力和生殖效率[1][2]。

[ 相关类别 ]:

研究领域 >> 内分泌

信号通路 >> 其他 >> 其他

[体外研究]

卵泡刺激素 (FSH)刺激卵巢颗粒细胞抑制素的产生,从而降低 FSH公司的产生[1]。

[体内研究]

卵泡刺激素 (1-4毫克/只羊; 肌肉注射; 每天 2.次, 共 2.天) 在植入 Norgestomet(HY-121677)的山羊中,增加黄体 (氯)总数、恢复的胚胎数和可转移的优质胚胎数[2]。动物模型：非哺乳期混合品种奶山羊植入诺孕酮[1]剂量：1 mg、2 mg、3 mg和4 mg；植入6 mg诺孕酮后治疗11 d给药：肌肉注射；结果：黄体总数(CL)增加,异常CL数量减少,胚胎恢复数量和高质量胚胎数量增加。

[参考文献]

[1]. Das N, et al. Molecular regulation of follicle-stimulating hormone synthesis, secretion and action. J Mol Endocrinol. 2018 Apr;60(3):R131-R155.

[2]. Pendleton R J, et al. Follicle stimulating hormone versus pregnant mare serum gonadotropin for superovulation of dairy goats. Small Ruminant Research, 1992, 8(3): 217-224.

卵泡刺激素物理化学性质

[ 外观性状 ]:
white powder

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: 50 mg/mL, soluble

卵泡刺激素安全信息

[ 危害码 (欧洲) ]:
B

[ 安全声明 (欧洲) ]:
22-24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
LP6330000

卵泡刺激素文献

Shortened estrous cycle length, increased FSH levels, FSH variance, oocyte spindle aberrations, and early declining fertility in aging senescence-accelerated mouse prone-8 (SAMP8) mice: concomitant characteristics of human midlife female reproductive aging.

Endocrinology 155(6) , 2287-300, (2014)

Women experience a series of specific transitions in their reproductive function with age. Shortening of the menstrual cycle begins in the mid to late 30s and is regarded as the first sign of reproduc...

Regulatory Role of Gonadotropins and Local Factors Produced by Ovarian Follicles on In Vitro Resistin Expression and Action on Porcine Follicular Steroidogenesis.

Biol. Reprod. 92 , 142, (2015)

Resistin, a hormone secreted by adipocytes, is thought to be important in reproduction. Our previous study demonstrated resistin expression in porcine ovarian follicles and its direct effect on steroi...

Longer anogenital distance is associated with higher testosterone levels in women: a cross-sectional study.

BJOG 121(11) , 1359-64, (2014)

Animal models have suggested that anogenital distance (AGD) at birth reflects androgen levels during in utero development and predicts adult AGD. A recent study showed an association between perineal ...

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