63717-27-1

• 常用中文名：氨磷汀一水物
• 常用英文名：Amifostine Hydrate
• CAS号：63717-27-1
• 分子式：C₅H₁₇N₂O₄PS
• 分子量：232.23800
• 发布时间：2018-03-11 08:00:00
• 更新时间：2026-07-01 18:51:49

名称

• 中文名: 氨磷汀一水物
• 英文名: 2-(3-aminopropylamino)ethylsulfanylphosphonic acid,hydrate
• 中文别名: 氨基丙基氨基乙基硫代磷酸酯一水合物
• 英文别名: Amifostina; Amifostinum; amifostine monohydrate; Phosphorothioic acid 2-((3-aminopropyl)amino)ethanethiol S-ester hydrate; Ethanethiol, 2-((3-aminopropyl)amino)-, dihydrogen phosphate (ester) hydrate; AMIFOSTINE HYDRATE; Amifostine hydrate; 2-((3-aminopropyl)amino)-ethanethiodihydrogenphosphate(ester)hydrate; phosphorothioicacid,s-(2-((3-aminopropyl)amino)ethyl)ester,hydrate; phosphorothioicacid,s-esterwith2-((3-aminopropyl)amino)ethanethiol,hydra; Phosphorothioic acid, S-ester with 2-((3-aminopropyl)amino)ethanethiol, hydrate; Amifostina [inn-spanish]; Amifostinum [INN-Latin]

物化性质

• 沸点: 441.7ºC at 760 mmHg
• 分子式: C₅H₁₇N₂O₄PS
• 分子量: 232.23800
• 闪点: 220.9ºC
• 精确质量: 232.06500
• PSA: 139.92000
• LogP: 0.77760
• 储存条件: 库房通风低温干燥

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TE6493000 CHEMICAL NAME : Phosphorothioic acid, S-(2-((3-aminopropyl)amino)ethyl) ester, hydrate CAS REGISTRY NUMBER : 63717-27-1 LAST UPDATED : 199009 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C5-H15-N2-O3-P-S.H2-O MOLECULAR WEIGHT : 232.27 WISWESSER LINE NOTATION : Z3M2SPQQO &QH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 700 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 12,236,1969 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 375 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 9,911,1966

合成路线

23545-42-8 ~% 63717-27-1

文献：WO2007/53730 A1, ; Page/Page column 14-15 ;

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