毒理学数据:
1.急性毒性 暂无资料
2.刺激性 暂无资料
3.致突变性 特异位点试验：果蝇经口100μmol/L。性染色体缺失和不分离：果蝇经口2μmol/L。DNA抑制：人Hela细胞5μmol/L（1h）
4.致癌性 IARC致癌性评论：IARC将砷及其无机化合物列为G1，确认人类致癌物。
5.其他 LDLo：20mg/kg（大鼠静脉内）
生态学数据:
1.生态毒性 暂无资料
2.生物降解性 暂无资料
3.非生物降解性 暂无资料
4.其他有害作用 该物质对环境有危害，应注意对水环境和蓄水层的污染。在对人类重要食物链中，特别是在植物中发生生物蓄积。
CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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CG0875000
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CHEMICAL NAME :
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Arsenic acid, disodium salt
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CAS REGISTRY NUMBER :
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7778-43-0
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LAST UPDATED :
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199712
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DATA ITEMS CITED :
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48
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MOLECULAR FORMULA :
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As-H-O4.2Na
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MOLECULAR WEIGHT :
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185.91
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WISWESSER LINE NOTATION :
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NA2 AS-O3-Q
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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34720 ug/kg
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TOXIC EFFECTS :
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Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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450 mg/kg/90D-C
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TOXIC EFFECTS :
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Brain and Coverings - other degenerative changes Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion) Biochemical - Neurotransmitters or modulators (putative) - catecholamine levels in CNS
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TYPE OF TEST :
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Specific locus test
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TYPE OF TEST :
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Specific locus test
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TYPE OF TEST :
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DNA inhibition
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TYPE OF TEST :
-
Mutation test systems - not otherwise specified
MUTATION DATA
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TYPE OF TEST :
-
Sister chromatid exchange
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TEST SYSTEM :
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Rodent - hamster Ovary
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REFERENCE :
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ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 4,493,1982 *** REVIEWS *** ACGIH TLV-TWA 0.01 mg(As)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-Confirmed human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.5 mg(As)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,16,1971 OSHA-cancer hazard CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1018,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.2 mg(As)/m3 JAN 1993 OEL-AUSTRALIA:TWA 0.05 mg(As)/m3;Carcinogen JAN 1993 OEL-BELGIUM:TWA 0.2 mg(As)/m3 JAN 1993 OEL-DENMARK:TWA 0.05 mg(As)/m3 JAN 1993 OEL-FINLAND;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.2 mg(As)/m3 JAN 1993 OEL-HUNGARY:STEL 0.5 mg(As)/m3;Carcinogen JAN 1993 OEL-INDIA:TWA 0.2 mg(As)/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.5 mg(As)/m3 JAN 1993 OEL-POLAND:TWA 0.3 mg(As)/m3 JAN 1993 OEL-SWEDEN:TWA 0.03 mg(As)/m3;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg(As)/m3;Carcinogen JAN 1993 OEL-THAILAND:TWA 0.5 mg(As)/m3 JAN 1993 OEL-TURKEY:TWA 0.5 mg(As)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.2 mg(As)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ARSENIC, INORGANIC-air:CA CL 0.002 mg(As)/m3/15M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992
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