865758-96-9

• 常用中文名：2-[(6-氯-34-二氢-3-甲基-24-二氧代-1(2H)-嘧啶基)甲基]苯甲腈(阿格列汀中间体)
• 常用英文名：2-[(6-Chloro-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl)methyl]benzonitrile
• CAS号：865758-96-9
• 分子式：C₁₃H₁₀ClN₃O₂
• 分子量：275.690
• 发布时间：2018-10-16 11:51:32
• 更新时间：2024-01-14 21:03:27

名称

• 中文名: 2-[(6-氯-3,4-二氢-3-甲基-2,4-二氧代-1(2H)-嘧啶)甲基]丁苯甲腈
• 英文名: 2-((6-Chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
• 中文别名: 阿格列汀-B; 2-[(6-氯-3,4-二氢-3-甲基-2,4-二氧代-1(2H)-嘧啶基)甲基]苯甲腈; 阿格列汀中间体; 苯甲酸阿格列汀中间体1
• 英文别名: 2-[(6-chloro-3-methyl-2,4-dioxopyrimidin-1-yl)methyl]benzonitrile; Benzonitrile, 2-[(6-chloro-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl)methyl]-; 2-[(6-Chloro-3-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl)methyl]benzonitrile; 2-[(6-Chloro-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl)methyl]benzonitrile; Alogliptin Impurity 7

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 418.0±55.0 °C at 760 mmHg
• 分子式: C₁₃H₁₀ClN₃O₂
• 分子量: 275.690
• 闪点: 206.6±31.5 °C
• 精确质量: 275.046143
• PSA: 67.79000
• LogP: 1.95
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.647
• 储存条件: 室温，干燥

安全

• 海关编码: 2933599090

合成路线

865758-95-8 74-88-4 ~72% 865758-96-9

文献：Feng, Jun; Gwaltney, Stephen L.; Stafford, Jeffrey A.; Zhang, Zhiyuan; Brodluahrer, Paul R.; Elder, Bruce; Isbester, Paul; Fornicola, Richard S.; Kisanga, Philip B.; Mobele, Bingidimi I.; Palmer, Grant J.; Reeve, Maxwell M.; Salsbury, Jonathon S.; Ulysse, Luckner; Venkatraman, Sripathy Patent: US2009/275750 A1, 2009 ; Location in patent: Page/Page column 22 ; US 20090275750 A1

74-88-4 ~72% 865758-96-9

文献：Andres, Mark; Lorimer, Keith Patent: US2007/66635 A1, 2007 ; Location in patent: Page/Page column 13-14; 14 ;

4318-56-3 22115-41-9 ~% 865758-96-9

文献：US2009/275750 A1, ; Page/Page column 23 ; US 20090275750 A1

1246610-72-9 ~71% 865758-96-9

文献：MAPI PHARMA HK LIMITED; MAROM, Ehud; MIZHIRITSKII, Michael; RUBNOV, Shai Patent: WO2010/109468 A1, 2010 ; Location in patent: Page/Page column 26 ;

22115-41-9 ~% 865758-96-9

文献：Journal of Medicinal Chemistry, , vol. 50, # 10 p. 2297 - 2300

上下游产品

上游产品  4
865758-95-8 74-88-4 4318-56-3 22115-41-9
下游产品  0

海关

海关编码	2933599090
中文概述	2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%