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16298-90-1

16298-90-1结构式
16298-90-1结构式
  • 常用中文名:jesaconitine
  • 常用英文名:jesaconitine
  • CAS号:16298-90-1
  • 分子式:C35H49NO12
  • 分子量:675.76
  • 相关类别: 研究领域 心血管疾病
  • 发布时间:2016-09-10 02:22:51
  • 更新时间:2024-01-18 11:25:55
  • 副乌头碱是一种有毒生物碱。乌头碱可以从乌头中提取。乌头碱是乌头中毒后右心房血液中可检测到的主要代谢产物之一。乌头碱中毒具有多种类型的心律失常特征[1]。

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英文名 (1α,3α,6α,14α,15α,16β)-8-Acetoxy-20-ethyl-3,13,15-trihydroxy-1,6, 16-trimethoxy-4-(methoxymethyl)aconitan-14-yl 4-methoxybenzoate
英文别名 N-Desethyl-N-Methylaconitine
Mesaaconitine
Japaconitine A
Japaconitine B
Jesaconitine
描述 副乌头碱是一种有毒生物碱。乌头碱可以从乌头中提取。乌头碱是乌头中毒后右心房血液中可检测到的主要代谢产物之一。乌头碱中毒具有多种类型的心律失常特征[1]。
相关类别
参考文献

[1]. Natori Y, et al. A simple and rapid method for quantifying aconitines and their metabolites in whole blood by modified QuEChERS and liquid chromatography/tandem mass spectrometry (LC/MS/MS). Forensic Sci Int. 2022 Dec;341:111475.  

密度 1.37g/cm3
沸点 748.1ºC at 760 mmHg
分子式 C35H49NO12
分子量 675.76
闪点 406.2ºC
精确质量 675.32500
PSA 162.68000
LogP 0.59460
蒸汽压 1.66E-23mmHg at 25°C
折射率 1.608

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AR5562540
CHEMICAL NAME :
Aconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, 8-acetate 14-(4-methoxybenzoate), (1-alpha,3-alpha,6-alpha,14-alpha,15-alpha,16-beta)-
CAS REGISTRY NUMBER :
16298-90-1
BEILSTEIN REFERENCE NO. :
0075405
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C35-H49-N-O12
MOLECULAR WEIGHT :
675.85

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
350 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 15,180,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
230 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 39,379,1991
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
80 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 23,873,1981
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
50 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 23,873,1981
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
30 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 23,873,1981