120511-88-8

• 常用中文名：2-[3-(1-氰基-1-甲基乙基)-5-(羟甲基)苯基]-2-甲基丙腈
• 常用英文名：Anastrozole EP Impurity E
• CAS号：120511-88-8
• 分子式：C₁₅H₁₈N₂O
• 分子量：242.31600
• 发布时间：2018-12-09 16:03:38
• 更新时间：2024-01-11 18:31:18

名称

• 中文名: 2-[3-(1-氰基-1-甲基乙基)-5-(羟甲基)苯基]-2-甲基丙腈
• 英文名: 2,2'-[5-(Hydroxymethyl)-1,3-phenylene]bis(2-methylpropanenitrile)
• 英文别名: 2-[3-bromomethyl-5-(cyano-dimethyl-methyl)-phenyl]-2-methyl-propionitrile; Methylpropiononitrile); 2,2'-(5-bromomethyl-1,3-phenylene)di(2-methylpropiononitrile); forAnastrozole; 5-BROMOMETHYLTETRAMETHYL-1,3-BENZENEDIACETONITRILE; 2,2'-(5-hydroxymethyl-1,3-phenylene)di(2-methylpropiononitrile); 5-BROMOMETHYL-A,A,A',A'-TETRAMETHYL-1,3-BENZENEDIACETONITRILE; [2,2'-(5-bromomethyl)-1,3-phenylene]di(2-methylpropio-nitrile); 2-[3-bromomethyl 5-(cyanodimethyl-methyl)-phenyl]-methyl propionitrile; 5-BROMOMETHYL-A,A,A',A'-TETRAMETHYL-1,3-BENZENEDIACETONITRIL; 3,5-Bis(1-cyano-1-methylethyl)bromomethylbenezene; 2-[3-(cyano-dimethyl-methyl)-5-hydroxymethyl-phenyl]-2-methyl-propionitrile; Anastrozole Impurity 10; Anastrozole EP Impurity E

物化性质

• 密度: 1.084
• 沸点: 382.3ºC at 760 mmHg
• 熔点: 150-160ºC
• 分子式: C₁₅H₁₈N₂O
• 分子量: 242.31600
• 闪点: 185ºC
• 精确质量: 242.14200
• PSA: 67.81000
• LogP: 2.78126

合成路线

871116-81-3 ~96% 120511-88-8

文献：Jackson, Toby; Woo, L. W. Lawrence; Trusselle, Melanie N.; Chander, Surinder K.; Purohit, Atul; Reed, Michael J.; Potter, Barry V. L. Organic and Biomolecular Chemistry, 2007 , vol. 5, # 18 p. 2940 - 2952

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