1105067-90-0

• 常用中文名：阿托伐他汀L1非对映体
• 常用英文名：10-trans-Atorvastatin Acetonide tert-Butyl Ester
• CAS号：1105067-90-0
• 分子式：C₄₀H₄₇FN₂O₅
• 分子量：654.81000
• 发布时间：2017-07-29 08:00:36
• 更新时间：2026-09-11 07:58:02

名称

• 中文名: 阿托伐他汀L1非对映体
• 英文名: tert-butyl 2-[(4S,6R)-6-[2-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate
• 中文别名: 叔丁基 2-((4S,6R)-6-(2-(2-(4-氟苯基)-5-异丙基-3-苯基-4-(苯基氨基甲酰基)-1H-吡咯-1-基)乙基) -2,2-二甲基-1,3-二噁烷-4-基)乙酸酯; 阿托伐他汀杂质66; 阿托伐他汀L1非对映体(阿托伐他汀杂质17); 阿托伐他汀L1非对映异构体1; 阿托伐他汀钙杂质39; 阿托伐他汀钙杂质39对照品; 1,1-二甲基乙基(4S,6R)-6-[2-[2-(4-氟苯基)-5-(1-甲基乙基)-3-苯基-4-[(苯胺基)羰基]-1H-吡咯-1-基]乙基]-2,2-二甲基-1,3-二恶烷-4-乙酸酯; 10-反式 - 阿托伐他汀丙酮化物叔丁酯
• 英文别名: Atorvastatin Acetonide t-Butyl Ester (4S, 6R)-Isomer; 1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4S,6R); (4S,6R)-6-[2-[2-(4-Fluorophenyl)-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-diMethyl-1,3-dioxane-4-acetic Acid 1,1-DiMethylethyl Ester; (4S,6R)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenyl amino) carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid t-butyl ester; Atorvastatin calcium-26; tert-butyl 2-[(4S,6R)-6-[2-[2-(4-fluorophenyl)-3-phenyl-4-(phenylcbamoyl)-5-propan-2-ylpyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate; Atorvastatin L1 Diastereomer; tert-butyl 2-((4S,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl -4-(phenylcbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan -4-yl)acetate; (3S,5R)-Atorvastatin Acetonide tert-Butyl Ester; Atorvastatin Protected Diol Diastereomer Impurity; Atorvastatin L1 Diastereomer （Atorvastatin Impurity 17）; Atorvastatin calcium impurity 39; Atorvastatin impurity 25/10-trans-Atorvastatin Acetonide tert-Butyl Ester/(4S,6R)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester; (4S,6R)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester; tert-butyl (4S,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxane-4-acetate

物化性质

• 分子式: C₄₀H₄₇FN₂O₅
• 分子量: 654.81000
• 精确质量: 654.34700
• PSA: 82.28000
• LogP: 9.75300

合成路线

1105067-89-7 125971-96-2 ~% 1105067-90-0 125971-95-1

文献：Stach, Jan; Havlicek, Jaroslav; Placek, Lukas; Radl, Stanislav Collection of Czechoslovak Chemical Communications, 2008 , vol. 73, # 2 p. 229 - 246

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