194934-95-7

• 常用中文名：(E)-5-羟基-3-氧代-7-[3’-(4’’-氟苯基)-1’-(1’’-甲基乙基)吲哚-2’-基]-6-庚烯酸叔丁酯
• 常用英文名：tert-Butyl (E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-6-heptenoate
• CAS号：194934-95-7
• 分子式：C₂₈H₃₂FNO₄
• 分子量：465.55600
• 相关类别： 原料药 循环系统用药 抗动脉粥样硬化药
• 发布时间：2018-12-05 18:59:16
• 更新时间：2026-09-01 07:38:52

名称

• 中文名: (E)-5-羟基-3-氧代-7-[3’-(4’’-氟苯基)-1’-(1’’-甲基乙基)吲哚-2’-基]-6-庚烯酸叔丁酯
• 英文名: tert-Butyl (E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-6-heptenoate
• 中文别名: (E)-5-羟基-3-氧代-7-[3'-(4''-氟苯基)-1'-(1''-甲基乙基); (E)- (±)-7-[3-(4-氟苯基)-1-(1-甲基乙基)-2-吲哚]-5-羟基-3-羰基-6-烯庚酸叔丁酯; (E)-(±)-7-[3-(4-氟苯基)-1-(1-甲基乙基)-2-吲哚]-5-羟基-3-羰基-6-烯庚酸叔丁酯; 氟伐他汀杂质18; 氟伐他汀中间体,叔丁基(±)-(E)-7-[3'-(4"-氟苯基)-1'-(1"-甲基乙基)吲哚 -2'-基]-3-羟基 -5-氧代-6-庚烯酸酯; 2 F-3(E)-5-羟基-3-氧代-7-[3-(4-氟苯基)-1-(1-甲基乙基)吲哚-2-基]-6-庚烯酸叔丁酯; F-3(E)-5-羟基-3-氧代-7-[3-(4-氟苯基)-1-(1-甲基乙基)吲哚-2-基]-6-庚烯酸叔丁酯; (E)-5-羟基-3-氧代-7-[3'-(4''-氟苯基)-1'-(1''-甲基乙基)吲哚-2'-基]-6-庚烯酸叔丁酯
• 英文别名: O-tert-Butyl-3-keto Fluvastatin; (E)-7-(3-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)INDOL-2-YL )-5-HYDROXY-3-OXOHT-6-ENOIL ACID TERT BUTYL ESTER; Fluvastatin Impurity 18; tert-Butyl (E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-in; Fluvastatin tert-butyl ester; FHH: FLUVASTATIN INTERMEDIATE; tert-Butyl (E)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-6-htenoate //BP; (tert-Butylester)(E)-6-Htenoicacid,7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-Tert-butylester; 7-[3-(4-fluorophenyl)-1-propan-2-yl-2-indolyl]-5-hydroxy-3-oxo-6-htenoic acid tert-butyl ester; 7-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-6-htenoic acid 1,1-dimethylethyl ester; O-tert-Butyl-3-keto Fluvastatin //BP; (E)- (±)-7-[3-(4-Fluorophenyl)-1-(1-Methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-6-htenoic acid 1, 1-diMethylethyl ester; 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-Tert-butylester; (E)-tert-Butyl 7-(3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl)-5-hydroxy-3-oxoht-6-enoate; (E)-6-Htenoicacid,7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-Tert-butylester; TERT-BUTYL (E)-7-[3-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-1H-INDOL-2-YL]-5-HYDROXY-3-OXO-6-HTENOATE; 6-Htenoic acid, 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-5-hydroxy-3-oxo-, 1,1-dimethylethyl ester, (5S,6E); (E)-(±)-7-[3- (4-fluorophenyl)-1-(-1-Methylethyl)-1H-indol-2-yl]-3, 5-dihydroxy-6-htenoic acid 1,1-diMethyl ester; (E)-7-(3-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)INDOL-2-YL )-5-HYDROXY-3-OXOHEPT-6-ENOIL ACID TERT BUTYL ESTER

物化性质

• 密度: 1.13
• 沸点: 647.7ºC at 760 mmHg
• 分子式: C₂₈H₃₂FNO₄
• 分子量: 465.55600
• 精确质量: 465.23200
• PSA: 68.53000
• LogP: 6.09340
• 蒸汽压: 1.16E-17mmHg at 25°C
• 折射率: 1.552

合成路线

540-88-5 95061-51-1 93957-50-7 ~% 108998-83-0 详细

文献：Tetrahedron, , vol. 53, # 31 p. 10659 - 10670

上下游产品

上游产品  3
540-88-5 95061-51-1 93957-50-7
下游产品  2
94061-80-0 194934-96-8