147511-70-4

• 常用中文名：匹伐他汀中间体PB7
• 常用英文名：(3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]- 3,5-dihydrosy-6-heptane acid,
• CAS号：147511-70-4
• 分子式：C₃₃H₃₅FN₂O₄
• 分子量：542.640
• 发布时间：2018-08-06 18:42:24
• 更新时间：2026-07-15 12:21:07

名称

• 中文名: (3R,5S)-7-[2-环丙基-4-(4-氟苯基)-3-喹啉-基]-3,5-二羟基-6-庚酸(+)苯乙胺
• 英文名: (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]- 3,5-dihydrosy-6-heptane acid,
• 中文别名: (3R,5S,6E)-7-[2-环丙基-4-(4-氟苯基)-3-喹啉基]-3,5-二羟基-6-庚烯酸:R-(+)-α-苯乙胺盐(1:1); 匹伐他汀杂质PF-BA甲基苄胺; (3R,5S,E)-7-(2-环丙基-4-(4-氟苯基)喹啉-3-基)-3,5-二羟基庚-6-烯酸酯 (R)-1-苯乙-1-胺盐; 匹伐他汀杂质N1; (3R,5S,E)-7-(2-环丙基-4-(4-氟苯基)喹啉-3-基)-3,5-二羟基-6-庚烯酸(R)-1-苯乙胺盐; 匹伐他汀杂质; (3R,5S)-7-[2-环丙基-4-(4-氟苯基)-3-喹啉基]-3,5-二羟基-6-庚烯酸 (+)-苯乙胺盐
• 英文别名: (R)-1-Phenylethan-1-amine (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyht-6-enoate; 1-phenyl-1-pentanol; (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-Htenoic acid, compd. with -a-methylbenzenemethanamine; (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid (R)-1-phenylethylamine salt; Pitavastatin (R)-alfa-Methylbenzylamine Salt; (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]- 3,5-dihydrosy-6-htane acid; pitavastatin phenylethanamine salt; (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-htenoic acid: R-(+)-α-benzylethylamine salt (1:1); y-6-htenoic acid tert-butyl ester (3R,5S)-7-[2 cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]; Pitavastatin (+)-Phenylethylamine; phenyl n-butyl carbinol; (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5; 6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, (3R,5S,6E)-, compd. with (αR)-α-methylbenzenemethanamine (1:1); (R)-1-phenylethanamine (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyht-6-enoate; Pitavastatin methylbenzylamine; (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydrosy-6-htaneacid,(+)phenylethylamine; (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-htenoic acid (+)-phenylethylamine salt; (R)-Butyl phenyl carbinol; pitavastatin (R)-1-phenylethylamine salt; Pivastatin (phenylethylamine salt); (R)-1-Phenylpentanol; (+)-1-Phenylpentanol; Pitavastatin Impurity N1; (R)-1-phenyl-1-pentanol; Pitavastatin Calcium Inter; (R)-1-Phenylethanamine (3R,5S,E)-7-(2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxy-6-htenoate; (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid - (1R)-1-phenylethanamine (1:1); (R)-1-phenylpentan-1-ol; P-2: (3R, 5S)-7-[2-Cyclopropyl-4-(4-Fluorophenyl)-3; 6-Htenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl] -3,5-dihy -droxy-, (3R,5S,6E)-, coMpd. with (R)-MethylbenzeneMethanaMine (1:1); (+)-1-Phenylpentan-1-ol; (R)-1-phenylethanamine (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate

物化性质

• 密度: 0.691 g/cm3
• 沸点: 14.2ºC at 760 mmHg
• 分子式: C₃₃H₃₅FN₂O₄
• 分子量: 542.640
• 精确质量: 542.258057
• PSA: 116.67000
• LogP: 6.92470

合成路线

586966-54-3 3886-69-9 ~% 147511-70-4

文献：WO2012/63254 A1, ; Page/Page column 11 ;

121660-37-5 ~% 147511-70-4

文献：WO2012/63254 A1, ;

121660-11-5 ~% 147511-70-4

文献：WO2012/63254 A1, ;

154057-56-4 ~% 147511-70-4

文献：WO2012/63254 A1, ;

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