86436-33-1

• 常用中文名：N-Hydroxyacetyldemecolcine
• 常用英文名：N-Hydroxyacetyldemecolcine
• CAS号：86436-33-1
• 分子式：C₂₃H₂₇NO₇
• 分子量：429.46300
• 发布时间：2017-08-05 07:13:32
• 更新时间：2024-04-02 17:43:56

名称

• 英文名: 2-hydroxy-N-methyl-N-(1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide
• 英文别名: N-Methylcolchifoline; N-(hydroxyacetyl)demecolcine; Democolcine,N-hydroxyacetyl; 2-hydroxy-n-methyl-n-(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide; Acetamide,2-hydroxy-N-methyl-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)

物化性质

• 密度: 1.3g/cm3
• 沸点: 723ºC at 760 mmHg
• 分子式: C₂₃H₂₇NO₇
• 分子量: 429.46300
• 闪点: 391.1ºC
• 精确质量: 429.17900
• PSA: 94.53000
• LogP: 2.18620
• 折射率: 1.599

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AC3662400 CHEMICAL NAME : Acetamide, 2-hydroxy-N-methyl-N-(5,6,7,9-tetrahydro-1,2,3,10-tet ramethoxy-9-oxobenzo( a) heptalen-7-yl)- CAS REGISTRY NUMBER : 86436-33-1 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C23-H27-N-O7 MOLECULAR WEIGHT : 429.51 WISWESSER LINE NOTATION : T B677 MV&T&J CO1 DO1 EO1 JN1&V1Q NO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6228 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,1365,1983

合成路线

477-30-5 78517-62-1 ~% 86436-33-1

文献：Brossi; Sharma; Atwell; Jacobson; Iorio; Molinari; Chignell Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1365 - 1369

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