10350-81-9

• 常用中文名：Phenol,4-[(7-chloro-4-quinolinyl)amino]-2-(1-pyrrolidinylmethyl)-, hydrochloride (1:2)
• 常用英文名：Phenol,4-[(7-chloro-4-quinolinyl)amino]-2-(1-pyrrolidinylmethyl)-, hydrochloride (1:2)
• CAS号：10350-81-9
• 分子式：C₂₀H₂₁Cl₂N₃O
• 分子量：390.30600
• 发布时间：2017-11-11 09:23:10
• 更新时间：2024-01-12 10:02:19

名称

• 英文名: Phenol,4-[(7-chloro-4-quinolinyl)amino]-2-(1-pyrrolidinylmethyl)-, hydrochloride (1:2)
• 英文别名: 4-(7-Chlor-chinolyl-(4)-amino)-2-pyrrolidinomethyl-phenol-dihydrochlorid; 1-Naphthol,4-((7-chloro-4-quinolyl)amino)-2-((diethylamino)methyl)-5,6,7,8-tetrahydro; 4-(7-chloro-quinolin-4-ylamino)-2-diethylaminomethyl-5,6,7,8-tetrahydro-naphthalen-1-ol; 1-Naphthalenol,4-((7-chloro-4-quinolinyl)amino)-2-((diethylamino)methyl)-5,6,7,8-tetrahydro; 4-(7-Chlor-4-chinolylamino)-2-diethylaminomethyl-5,6,7,8-tetrahydro-I-naphthol

物化性质

• 密度: 1.351g/cm3
• 沸点: 498.1ºC at 760mmHg
• 分子式: C₂₀H₂₁Cl₂N₃O
• 分子量: 390.30600
• 闪点: 255.1ºC
• 精确质量: 389.10600
• PSA: 48.39000
• LogP: 5.74610

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : GO7350000 CHEMICAL NAME : o-Cresol, 4-((7-chloro-4-quinolyl)amino)-alpha-1-pyrrolidinyl-, dihydrochloride CAS REGISTRY NUMBER : 10350-81-9 LAST UPDATED : 199709 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C20-H20-Cl-N3-O.2Cl-H MOLECULAR WEIGHT : 426.80 WISWESSER LINE NOTATION : T66 BNJ IG EMR DQ C1- AT5NTJ &GH 2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 410 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 8,450,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 34 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 8,450,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 580 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - other changes REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 8,450,1958 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 35 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 8,450,1958 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : AJTHAB American Journal of Tropical Medicine and Hygiene. (Allen Press, 1041 New Hampshire St., Lawrence, KS 66044) V.1- 1952- Volume(issue)/page/year: 6,987,1957 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 36876 mg/kg/12W-C TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - dehydration Related to Chronic Data - death REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 8,450,1958 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 1320 mg/kg/2W-I TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Gastrointestinal - nausea or vomiting Related to Chronic Data - death REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 8,450,1958 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 120 mg/kg/16D-I TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 8,450,1958