88254-07-3

• 常用中文名：5,12-Naphthacenedione,10-[[3-(3-cyano-4-morpholinyl)-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-,(8S,10S)-
• 常用英文名：5,12-Naphthacenedione,10-[[3-(3-cyano-4-morpholinyl)-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-,(8S,10S)-
• CAS号：88254-07-3
• 分子式：C₃₂H₃₄N₂O₁₂
• 分子量：638.61900
• 发布时间：2017-11-23 01:25:52
• 更新时间：2023-01-16 13:45:20

名称

• 英文名: 3'-deamino-3'-(3-cyanomorpholin-4-yl)doxorubicin
• 英文别名: 5,12-Naphthacenedione, 10-[[3-(3-cyano-4-morpholinyl)-2,3,6-trideoxy-.α.- L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11- trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-; MRA-CN; 3'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin; cyanomorpholino-doxorubicin; 3'-Deamino-3'-(3-cyano-4-morpholinyl)adriamycin

物化性质

• 密度: 1.59g/cm3
• 沸点: 899.2ºC at 760 mmHg
• 分子式: C₃₂H₃₄N₂O₁₂
• 分子量: 638.61900
• 闪点: 497.6ºC
• 精确质量: 638.21100
• PSA: 216.31000
• LogP: 0.20488
• 折射率: 1.697

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QI9405000 CHEMICAL NAME : 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-10-((3-(3-cyanomorpholino)-2,3,6- trideoxy- alpha-L-lyxo-hexopyranosyl)oxy)-8-(hydroxyacetyl)-1-m ethoxy-6,8,11-trihydr oxy-, (8s-cis)- CAS REGISTRY NUMBER : 88254-07-3 LAST UPDATED : 199612 DATA ITEMS CITED : 16 MOLECULAR FORMULA : C32-H34-N2-O12 MOLECULAR WEIGHT : 638.68 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 10 ug/kg TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors MUTATION DATA TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 30 ng/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 44,5599,1984

合成路线

7456-83-9 25316-40-9 ~0% 89164-77-2 80875-73-6 详细

文献：Acton; Tong; Mosher; Wolgemuth Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 638 - 645

7456-83-9 25316-40-9 75-05-8 ~0% 89164-77-2 详细

文献：Acton; Tong; Mosher; Wolgemuth Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 638 - 645

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