2582-07-2

• 常用中文名：(2-Benzothiazolyl)-guanidine
• 常用英文名：(2-Benzothiazolyl)-guanidine
• CAS号：2582-07-2
• 分子式：C₈H₈N₄S
• 分子量：192.24100
• 发布时间：2016-11-26 05:39:08
• 更新时间：2024-01-11 19:29:03

名称

• 英文名: 2-(1,3-benzothiazol-2-yl)guanidine
• 英文别名: 1-(1,3-benzothiazol-2-yl)guanidine; GUANIDINE,(2-BENZOTHIAZOLYL); Benzothiazole guanidine; 2-benzthiazolylguanidine; 1-(benzo[d]thiazol-2-yl)guanidine; benzothiazolyl-2-guanidine; benzothiazolylguanidine; Benzothiazol-2-ylguanidine; 2-(benzothiazolyl)guanidine; 2-guanidinobenzothiazole; EINECS 219-955-1

物化性质

• 密度: 1.57g/cm3
• 沸点: 405.2ºC at 760 mmHg
• 分子式: C₈H₈N₄S
• 分子量: 192.24100
• 闪点: 198.9ºC
• 精确质量: 192.04700
• PSA: 103.03000
• LogP: 2.47470
• 蒸汽压: 8.92E-07mmHg at 25°C
• 折射率: 1.799

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : ME8513000 CHEMICAL NAME : Guanidine, (2-benzothiazolyl)- CAS REGISTRY NUMBER : 2582-07-2 LAST UPDATED : 198611 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C8-H8-N4-S MOLECULAR WEIGHT : 192.26 WISWESSER LINE NOTATION : T56 BN DSJ CMYZUM HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 56 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02533 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Endocrine - hyperglycemia REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 54,17,1935 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 41,127,1931

安全

• 海关编码: 2934200090

合成路线

127099-85-8 137-07-5 ~97% 2582-07-2

文献：Dolzhenko, Anton V.; Chui, Wai-Keung; Dolzhenko, Anna V. Synthesis, 2006 , # 4 p. 597 - 602

136-95-8 420-04-2 ~30% 2582-07-2

文献：Tsubokura, Kazuki; Iwata, Takayuki; Taichi, Misako; Kurbangalieva, Almira; Fukase, Koichi; Nakao, Yoichi; Tanaka, Katsunori Synlett, 2014 , vol. 25, # 9 p. 1302 - 1306

127099-85-8 ~% 2582-07-2

文献：Takahashi; Niino Yakugaku Zasshi, 1943 , vol. 63, p. 249,252 Chem.Abstr., 1951 , p. 5120 Full Text Show Details Smith; Mason; Carroll Journal of the American Chemical Society, 1931 , vol. 53, p. 4103,4105

136-95-8 867-44-7 ~24% 2582-07-2

文献：WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH; FOLDRX PHARMACEUTICALS, INC. Patent: WO2006/34003 A2, 2006 ; Location in patent: Page/Page column 75 ;

137-07-5 ~% 2582-07-2

文献：Sethi, Kalyan K.; Verma, Saurabh M.; Prasanthi, Naru; Annapurna, Mathrusri M. Letters in Drug Design and Discovery, 2011 , vol. 8, # 9 p. 774 - 777

上下游产品

上游产品  4
137-07-5 136-95-8 420-04-2 867-44-7
下游产品  0

海关

海关编码	2934200090
中文概述	2934200090. 其他含一个苯并噻唑环系的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934200090. other compounds containing in the structure a benzothiazole ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%