16053-52-4

• 常用中文名：1-((2R,4R,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-基)-5-甲基嘧啶-2,4(1H,3H)-二酮
• 常用英文名：2,4(1H,3H)-Pyrimidinedione,1-(2-deoxy-b-D-threo-pentofuranosyl)-5-methyl
• CAS号：16053-52-4
• 分子式：C₁₀H₁₄N₂O₅
• 分子量：242.23
• 相关类别： 信号通路 细胞周期/DNA损伤 核苷抗代谢药/类似物
• 发布时间：2019-01-06 07:32:48
• 更新时间：2026-07-11 07:12:46
• 1-(2-脱氧-β-D-苏基五呋喃基)胸腺嘧啶是胸苷类似物。该系列的类似物对复制的DNA具有插入活性。它们可以用于标记细胞和跟踪DNA合成[1]。

名称

• 中文名: 1-((2R,4R,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-基)-5-甲基嘧啶-2,4(1H,3H)-二酮
• 英文名: 1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
• 中文别名: 司他夫定杂质B; 1-(2-脱氧-Β-D-苏式-戊呋喃糖基)-5-甲基-2,4(1H,3H)-嘧啶二酮; 齐多夫定杂质M; 3'-Β-胸苷; 齐多夫定F; 西洛多辛杂质18 单体; 齐多夫定杂质F; 齐多夫定杂质6; 司他夫定杂质Ⅳ(胸苷异构体)
• 英文别名: Stavudine Impurity B (Zidovudine Impurity F); 1-((2S,4R,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; Stavudine Impurity B; 1-(2'-Deoxy-β-D-threo-pentofuranosyl)thymine; Zidovudine impurity F (M); 1-((2R,4R,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-MethylpyriMidine-2,4(1H,3H)-dione; 1-(2-Deoxy-β-D-threo-pentofuranosyl)-5-methyluricil; 1-(2-Deoxy-beta-D-threo-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione; Stavudine Impurit Ⅳ: 1-(2-Deoxy-β-D-threo-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione( 3'-β-Thymidine); 1-(2'-DEOXY-SS-THREOPENTOFURANOSYL)THYMINE; 3’-β-Thymidine; beta-T 1-(2-Deoxy-b-D-xylofuranosyl)-5-methyluracil, Zidovudine impurity 6,Zidovudine impurity M; 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-β-D-threo-pentofuranosyl)-5-methyl; 1-(2-Deoxy-beta-D-xylofuranosyl)-5-methyluracil, 3’-FddT, Alovudine; 1-(2-Deoxy-β-D-threo-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione; Zidovudine Impurity 6(Zidovudine Impurity F); 1-(2-deoxy-β-D-threo-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione; Zidovudine Impurity F (Stavudine Impurity B); Zidovudine impurity M; Stavudine impurity 2(B); 1-(2-Deoxy-beta-D-xylofuranosyl)-5-methyluracil; Stavudine Impurit Ⅳ: 1-(2-Deoxy-β-D-threo-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione( 3’-β-Thymidine); 1-(2-Deoxy-b-D-xylofuranosyl)-5-methyluracil; 1-(2-Deoxy-D-xylofuranosyl)-5-methyluracil; 1-(2-Deoxy-b-D-xylofurano syl)-5-methyluracil, 3’-beta-thymidine; 3'-β-Thymidine; 1-(2-deoxy-β-D-threo-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione (3′-ithymidine); 1-(2-Deoxy-β-D-threopentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione; L-2'-deoxythymidine; Thymidine 3''-imer; Zidovudine Impurity F; 1-(2'-deoxy-beta-threopentofuranosyl)thymine; Silodosin Impurity 18 Monomer

物化性质

• 密度: 1.452g/cm3
• 分子式: C₁₀H₁₄N₂O₅
• 分子量: 242.23
• 精确质量: 242.09000
• PSA: 104.55000
• 折射率: 1.584

生物活性

• 描述: 1-(2-脱氧-β-D-苏基五呋喃基)胸腺嘧啶是胸苷类似物。该系列的类似物对复制的DNA具有插入活性。它们可以用于标记细胞和跟踪DNA合成[1]。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 其他
• 参考文献:

  [1]. Cavanagh BL, et al. Thymidine analogues for tracking DNA synthesis. Molecules. 2011 Sep 15;16(9):7980-93.

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