42472-93-5

• 常用中文名：N-METHYL-2-PHTHALIMIDOGLUTARIMIDE
• 常用英文名：N-METHYL-2-PHTHALIMIDOGLUTARIMIDE
• CAS号：42472-93-5
• 分子式：C₁₄H₁₂N₂O₄
• 分子量：272.25600
• 发布时间：2016-10-08 06:20:46
• 更新时间：2024-01-26 12:59:42

名称

• 英文名: 2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
• 英文别名: 6-Methyl-2-phthalimido-glutarimid; methyl-thalidomide; Glutarimide,N-methyl-2-phthalimido; N-methyl thalidomide; 2-Phthalimido-N-methyl-glutarimide; 2-(1-methyl-2,6-dioxopiperidin-3-yl)-1h-isoindole-1,3(2h)-dione; N-Methyl-2-phthalimidoglutarimide

物化性质

• 密度: 1.457g/cm3
• 沸点: 477ºC at 760 mmHg
• 分子式: C₁₄H₁₂N₂O₄
• 分子量: 272.25600
• 闪点: 232ºC
• 精确质量: 272.08000
• PSA: 74.76000
• LogP: 0.30580
• 折射率: 1.64

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : MA5300000 CHEMICAL NAME : Glutarimide, N-methyl-2-phthalimido- CAS REGISTRY NUMBER : 42472-93-5 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C14-H12-N2-O4 MOLECULAR WEIGHT : 272.28 WISWESSER LINE NOTATION : T56 BVNVJ C- DT6VNVTJ B1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 670 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 3,721,1964 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 650 mg/kg SEX/DURATION : female 4-16 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - body wall Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - other developmental abnormalities REFERENCE : LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 3,721,1964

合成路线

74-89-5 3343-28-0 ~68% 42472-93-5

文献：Goosen; Laing; Plessis; Flynn Pharmaceutical Research, 2002 , vol. 19, # 1 p. 13 - 19

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