CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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TX8257000
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CHEMICAL NAME :
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1,3-Propanediamine, N-(1-methylethyl)-N'-(1-nitro-9-acridinyl)-, dihydrochloride
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CAS REGISTRY NUMBER :
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63710-43-0
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LAST UPDATED :
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198910
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DATA ITEMS CITED :
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11
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MOLECULAR FORMULA :
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C19-H22-N4-O2.2Cl-H
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MOLECULAR WEIGHT :
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411.37
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WISWESSER LINE NOTATION :
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T C666 BNJ HNW JM3MY1&1 &GH 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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127 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Gastrointestinal - hypermotility, diarrhea
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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900 ug/kg
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TOXIC EFFECTS :
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Behavioral - changes in motor activity (specific assay)
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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126 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Gastrointestinal - hypermotility, diarrhea
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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2170 ug/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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2 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Gastrointestinal - hypermotility, diarrhea
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Bird - pigeon
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DOSE/DURATION :
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2100 ug/kg
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TOXIC EFFECTS :
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Gastrointestinal - nausea or vomiting
MUTATION DATA
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TYPE OF TEST :
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Sister chromatid exchange
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TEST SYSTEM :
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Human Lymphocyte
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DOSE/DURATION :
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80 nmol/L/69H
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REFERENCE :
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MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 67,93,1979
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