79-85-6

• 常用中文名：(4R,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide
• 常用英文名：(4R,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide
• CAS号：79-85-6
• 分子式：C₂₂H₂₄N₂O₈
• 分子量：444.43500
• 相关类别： 有机原料 有机氟化合物 氟丙烷系列
• 发布时间：2016-02-17 04:40:54
• 更新时间：2024-03-02 19:36:28

名称

• 英文名: (4R,4aS,5aS,6S,12aR)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide
• 英文别名: 4-epi-tetracycline; 4'epi-N-TFA-daunorubicin; Daunorubicin,N-(trifluoro-acetyl); (4aS)-4t-dimethylamino-3,6t,10,12,12a-pentahydroxy-6c-methyl-1,11-dioxo-(4ar,5ac,12ac)-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide; 4'epi-N-trifluoroacetyl-daunorubicin; Epi-tetracycline

物化性质

• 密度: 1.64 g/cm3
• 沸点: 682.8ºC at 760 mmHg
• 分子式: C₂₂H₂₄N₂O₈
• 分子量: 444.43500
• 闪点: 366.7ºC
• 精确质量: 444.15300
• PSA: 181.62000
• LogP: 0.48590
• 折射率: 1.74

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : QI9277680 CHEMICAL NAME : 2-Naphthacenecarboxamide, 1,4,4a,5,5a,6,11,12a-octahydro-4-(dimethylamino)-1,11 -dioxo-6- methyl-3,6,10,12,12a-pentahydroxy-, 4-epimer CAS REGISTRY NUMBER : 79-85-6 LAST UPDATED : 199709 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C22-H24-N2-O8 MOLECULAR WEIGHT : 444.48 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 85800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year: 13,244,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 84800 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 40YJAX "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity Risks In New Drugs, Proceedings of the Symposium on Toxicological Testing for Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague, Czechoslovakia, Univerzita Karlova, 1979 Volume(issue)/page/year: -,55,1979