857629-78-8

• 常用中文名：(E)-3-O-甲基恩他卡朋
• 常用英文名：(E)-3-O-Methyl Entacapone
• CAS号：857629-78-8
• 分子式：C₁₅H₁₇N₃O₅
• 分子量：319.313
• 发布时间：2016-12-14 00:28:16
• 更新时间：2026-07-15 17:32:44

名称

• 中文名: (E)-3-O-甲基恩他卡朋
• 英文名: (E)-2-cyano-N,N-diethyl-3-(4-hydroxy-3-methoxy-5-nitrophenyl)prop-2-enamide
• 中文别名: 恩他卡朋杂质70; 安托卡朋杂质G; 恩他卡朋杂质22; 恩他卡朋甲氧基杂质; 恩他卡朋杂质G
• 英文别名: (2E)-2-Cyano-N,N-diethyl-3-(4-hydroxy-3-Methoxy-5-nitrophenyl)-2-propenaMide; Entacapone IMpurity G; 2-Propenamide, 2-cyano-N,N-diethyl-3-(4-hydroxy-3-methoxy-5-nitrophenyl)-, (2E); Entacapone Impurity 70; Entacapone 3-Methyl Ether; (E)-2-Cyano-N,N-diethyl-3-(4-hydroxy-3-methoxy-5-nitrophenyl)acrylamide; 3-O-methylentacapone; Entacapone Impurity 22; (2E)-2-cyano-N,N-diethyl-3-(4-hydroxy-3-methoxy-5-nitrophenyl)prop-2-enamide; (2E)-2-Cyano-N,N-diethyl-3-(4-hydroxy-3-methoxy-5-nitrophenyl)acrylamide

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 514.1±50.0 °C at 760 mmHg
• 分子式: C₁₅H₁₇N₃O₅
• 分子量: 319.313
• 闪点: 264.7±30.1 °C
• 精确质量: 319.116821
• PSA: 119.38000
• LogP: 2.18
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.602

合成路线

6635-20-7 26391-06-0 ~95% 857629-78-8

文献：Dipharma Francis S.r.l. Patent: EP1935873 A1, 2008 ; Location in patent: Page/Page column 5 ;

893419-47-1 ~94% 857629-78-8

文献：SUNSHINE LAKE PHARMA CO., LTD.; ZHOU, Dongsheng; LIU, Liu; MAO, Bin; LIU, Yun Patent: WO2013/149566 A1, 2013 ; Location in patent: Paragraph 0042 ;

6635-20-7 26391-06-0 ~% 158693-04-0 857629-78-8

文献：WO2005/63693 A1, ; Page/Page column 7-8 ;

893419-47-1 ~% 158693-04-0 857629-78-8

文献：WO2006/64296 A1, ; Page/Page column 6-7 ;

26391-06-0 ~% 857629-78-8

文献：Synthetic Communications, , vol. 42, # 9 p. 1359 - 1366

121-33-5 ~% 857629-78-8

文献：Synthetic Communications, , vol. 42, # 9 p. 1359 - 1366

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