949096-01-9

• 常用中文名：4-[3-(甲基氨基)-1-(2-噻吩基)丙基]-1-萘氢溴酸盐(度洛西汀杂质)
• 常用英文名：4-[3-(methylamino)-1-thiophen-2-ylpropyl]naphthalen-1-ol,hydrobromide
• CAS号：949096-01-9
• 分子式：C₁₈H₂₀BrNOS
• 分子量：378.32700
• 发布时间：2018-06-20 17:45:47
• 更新时间：2026-07-01 16:03:03

名称

• 中文名: 4-[3-(甲基氨基)-1-(2-噻吩基)丙基]-1-萘氢溴酸盐(度洛西汀杂质)
• 英文名: 4-[3-(methylamino)-1-thiophen-2-ylpropyl]naphthalen-1-ol,hydrobromide
• 中文别名: 度洛西汀杂质C HBR; 度洛西汀杂质C; 度洛西汀杂质HBR; 4-(3-(甲氨基)-1-(噻吩-2-基)丙基)萘-1-醇氢溴酸盐 (度洛西汀杂质); 度洛西汀杂质C氢溴酸盐; 度洛西汀杂质C(HBR); 度洛西汀杂质62; 4-[3-(甲氨基)-1-(2 -噻吩)丙基]-1-萘酚氢溴酸; 度洛西汀杂质C 溴化氢
• 英文别名: 4-(3-(Methylamino)-1-(thiophen-2-yl)propyl)naphthalen-1-ol hydrobromide (Duloxetine Impurity); Duloxetine Impurity62; Duloxetine 4-Naphthyl Isomer Hydrobromide; Duloxetine IMpurity HBr; 4-[3-(Methylamino)-1-(2-thienyl)propyl]; Duloxetine Impurity C HBr; (+/-)-N-methyl-3-(2-thienyl)-3-(4-hydroxy-naphthyl)-propylamine hydrogenbromide; Duloxetine Imp C; 4-(3-(methylamino)-1-(thiophen-2-yl)propyl)naphthalen-1-ol hydrobromide salt; 4-[(1RS)-3-(Methylamino)-1-(thiophen-2-yl)propyl]naphthalen-1-ol Hydrobromide; 4-[3-(Methylamino)-1-(2-thienyl)propyl]-1-naphthol hydrobromide (1:1); 4-[3-(Methylamino)-1-(2-thienyl)propyl]-1-naphthalenol Hydrobromide (Duloxetine Impurity); Duloxetine-4; Duloxetine impurity 3/Duloxetine Impurity C HBr/4-(3-(methylamino)-1-(thiophen-2-yl)propyl)naphthalen-1-ol hydrobromide salt

物化性质

• 分子式: C₁₈H₂₀BrNOS
• 分子量: 378.32700
• 精确质量: 377.04500
• PSA: 60.50000
• LogP: 5.69730

合成路线

116539-58-3 ~65% 949096-01-9

文献：EGIS GYOGYSZERGYAR NYRT Patent: WO2007/105021 A2, 2007 ; Location in patent: Page/Page column 29-30 ;

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