330792-70-6

• 常用中文名：3-氨基-4-氰基-5-(4-苯氧基苯基)吡唑
• 常用英文名：3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole
• CAS号：330792-70-6
• 分子式：C₁₆H₁₂N₄O
• 分子量：276.293
• 发布时间：2018-12-23 14:21:23
• 更新时间：2026-06-30 14:13:59

名称

• 中文名: 5-氨基-3-(4-苯氧基苯基)-1H-吡唑-4-甲腈
• 英文名: 3-Amino-5-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile
• 中文别名: 5-氨基-3-(4-苯氧基苯基)-1H-吡唑-4-腈; 依鲁替尼中间体N-3 IBL4; 3-氨基-5-(4-苯氢基苯基)-4-氛基-1H-吡唑; 伊布替尼中间体N-3; 伊鲁替尼 中间体4; 3-氨基-5-(4-苯氧基苯基)-4-氰基-1H-吡唑; 361、3-氨基-5-(4-苯氧基苯基)-4-氰基-1H-吡唑; 依鲁替尼中间体2; 3-氨基-5-(4-苯氧基苯基)-4-氰基-1H-吡唑(依鲁替尼中间体); 伊布替尼中间体3; 3-氨基-5-(4-苯氧基苯基)吡唑-4-甲腈; 依鲁替尼中间体N-3; INTERMEDIATE OF IBRUTINIB依鲁替尼5-AMINO-3-(4-PHENOXYPHENYL)-1H-PYRAZOLE-4-CBONITRILE; 3-氨基-5-(4-苯氧基苯基)-4-氰基-1H-吡唑(伊鲁替尼中间体); 伊布替尼杂质30; 依鲁替尼N-3中间体; 依鲁替尼中间体(N-2)(PLF-YLTN-N2)
• 英文别名: Ibrutinib intermediate3; Ibrutinib intermediates N-3; 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile; 5-Amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile; IbrutinibIntermediate4; Zanubrutinib KSM-II : (4-isocyano-3-(4-phenoxyphenyl)-1H-pyrazol-5-amine); Zanubrutinib Impurity 8; IbrutinibN-3; 1H-Pyrazole-4-carbonitrile, 3-amino-5-(4-phenoxyphenyl); 3-amino-5-(4-phenoxyphenyl)-1H-Pyrazole-4-carbonitrile; 3-amino-4-cyano oup-5-(4-Phenoxyphenyl)Pyrazole; Zanubrutinib impurity-20; 5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile; Zanubrutinib Related Compound 6; Zanubrutinib impurity-8 (3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 585.3±50.0 °C at 760 mmHg
• 分子式: C₁₆H₁₂N₄O
• 分子量: 276.293
• 闪点: 307.8±30.1 °C
• 精确质量: 276.101105
• PSA: 88.45000
• LogP: 3.80
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.699
• 储存条件: 室温，避光，保存于惰性气体中

合成路线

330792-69-3 ~89% 330792-70-6

文献：CENTAURUS BIOPHARMA CO., LTD.; HAN, Yongxin; YU, Rong; WANG, Zanping; LIANG, Zhi; HU, Quan; ZHU, Li; HU, Yuandong; SUN, Yinghui; ZHAO, Na; PENG, Yong; ZHAI, Xiaofeng; LUO, Hong; XIAO, Dengming Patent: WO2014/82598 A1, 2014 ; Location in patent: Paragraph 0379; 0378 ;

1623-95-6 109-77-3 ~17% 330792-70-6

文献：BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BENTZIEN, Joerg Martin; BERRY, Angela Kay; BOSANAC, Todd; BURKE, Michael Jason; DISALVO, Darren Todd; HORAN, Joshua Courtney; LIANG, Shuang; MAO, Can; MAO, Wang; SHEN, Yue; SOLEYMANZADEH, Fariba; ZINDELL, Renee M. Patent: US2014/45813 A1, 2014 ; Location in patent: Paragraph 0120 ;

21218-94-0 ~% 330792-70-6

文献：CENTAURUS BIOPHARMA CO., LTD.; HAN, Yongxin; YU, Rong; WANG, Zanping; LIANG, Zhi; HU, Quan; ZHU, Li; HU, Yuandong; SUN, Yinghui; ZHAO, Na; PENG, Yong; ZHAI, Xiaofeng; LUO, Hong; XIAO, Dengming Patent: WO2014/82598 A1, 2014 ;

2215-77-2 ~% 330792-70-6

文献：CENTAURUS BIOPHARMA CO., LTD.; HAN, Yongxin; YU, Rong; WANG, Zanping; LIANG, Zhi; HU, Quan; ZHU, Li; HU, Yuandong; SUN, Yinghui; ZHAO, Na; PENG, Yong; ZHAI, Xiaofeng; LUO, Hong; XIAO, Dengming Patent: WO2014/82598 A1, 2014 ;

1623-95-6 ~% 330792-70-6

文献：CENTAURUS BIOPHARMA CO., LTD.; HAN, Yongxin; YU, Rong; WANG, Zanping; LIANG, Zhi; HU, Quan; ZHU, Li; HU, Yuandong; SUN, Yinghui; ZHAO, Na; PENG, Yong; ZHAI, Xiaofeng; LUO, Hong; XIAO, Dengming Patent: WO2014/82598 A1, 2014 ;

619-44-3 ~% 330792-70-6

文献：CENTAURUS BIOPHARMA CO., LTD.; HAN, Yongxin; YU, Rong; WANG, Zanping; LIANG, Zhi; HU, Quan; ZHU, Li; HU, Yuandong; SUN, Yinghui; ZHAO, Na; PENG, Yong; ZHAI, Xiaofeng; LUO, Hong; XIAO, Dengming Patent: WO2014/82598 A1, 2014 ;

108-95-2 ~% 330792-70-6

文献：CENTAURUS BIOPHARMA CO., LTD.; HAN, Yongxin; YU, Rong; WANG, Zanping; LIANG, Zhi; HU, Quan; ZHU, Li; HU, Yuandong; SUN, Yinghui; ZHAO, Na; PENG, Yong; ZHAI, Xiaofeng; LUO, Hong; XIAO, Dengming Patent: WO2014/82598 A1, 2014 ;

上下游产品

上游产品  7
330792-69-3 1623-95-6 109-77-3 21218-94-0
2215-77-2 619-44-3 108-95-2
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