432-60-0

• 常用中文名：烯丙基雌烯醇
• 常用英文名：Allylestrenol
• CAS号：432-60-0
• 分子式：C₂₁H₃₂O
• 分子量：300.478
• 相关类别： 原料药 激素及调节内分泌功能类药 雌激素及孕激素类药
• 发布时间：2018-09-22 13:22:15
• 更新时间：2024-01-02 18:07:05
• Allylestrenol 是一种合成的性类固醇，在世界范围内用于濒危怀孕。

名称

• 中文名: 烯丙基雌烯醇
• 英文名: Allylestrenol
• 中文别名: 烯丙基雌醇; 烯丙雌醇
• 英文别名: allyloestrenol; 17α-Allyl-4-oestrene-17β-ol; EINECS 207-082-9; organon; allyl-estreno; 17-Allylestr-4-en-17b-ol; Estr-4-en-17β-ol, 17-allyl-; Estr-4-en-17-ol, 17-(2-propen-1-yl)-, (17β)-; (8R,9S,10R,13S,14S,17R)-17-Allyl-13-methyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol; 17α-Allylestr-4-en-17β-ol; MFCD00198957; 17-Hydroxy-17a-allyl-4-estrene; (17β)-17-(prop-2-en-1-yl)estr-4-en-17-ol; Estr-4-en-17-ol, 17-(2-propenyl)-, (17β)-; Estr-4-en-17-ol, 17- (2-propenyl)-, (17β)-; 17α-Allyl-17β-hydroxy-4-estrene; Gestanin; (17β)-17-prop-2-en-1-ylestr-4-en-17-ol; 17a-Allyl-17-hydroxy-19-nor-4-androstene; Turinal; allylestrenol; Orageston; 17α-Allyl-4-estren-17β-ol; Gestanon; gestanyn; Gestanol

物化性质

• 密度: 1.0±0.1 g/cm3
• 沸点: 405.4±44.0 °C at 760 mmHg
• 熔点: 78 - 81ºC
• 分子式: C₂₁H₃₂O
• 分子量: 300.478
• 闪点: 170.6±20.7 °C
• 精确质量: 300.245331
• PSA: 20.23000
• LogP: 6.64
• 外观性状: 白色结晶粉末
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.553
• 储存条件: 库房通风低温干燥,与食品原料分开存放

生物活性

• 描述: Allylestrenol 是一种合成的性类固醇,在世界范围内用于濒危怀孕。
• 相关类别:
  研究领域 >> 内分泌
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Pap E, et al. Effect of prenatal allylestrenol treatment (hormonal imprinting) on the serum testosterone and progesterone level in adult rats. Gen Pharmacol. 1995 Mar;26(2):365-7.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : KG7960000 CHEMICAL NAME : Estr-4-en-17-beta-ol, 17-allyl- CAS REGISTRY NUMBER : 432-60-0 BEILSTEIN REFERENCE NO. : 3148038 LAST UPDATED : 199612 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C21-H32-O MOLECULAR WEIGHT : 300.53 WISWESSER LINE NOTATION : L E5 B666 MUTJ E1 FQ F2U1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >640 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,41,1982 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 8 mg/kg SEX/DURATION : female 20 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955- Volume(issue)/page/year: 9,57,1964 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 900 mg/kg SEX/DURATION : female 13-21 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 65,29,1970 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 300 mg/kg SEX/DURATION : male 15 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct REFERENCE : IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913- Volume(issue)/page/year: 59,768,1971 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 15 mg/kg SEX/DURATION : male 15 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : IJMRAQ Indian Journal of Medical Research. (Indian Council of Medical Research, Ansari Nagar, New Delhi 110 029, India) V.1- 1913- Volume(issue)/page/year: 59,768,1971 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 175 mg/kg SEX/DURATION : female 15-21 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 38,128,1961 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 900 mg/kg SEX/DURATION : female 13-21 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 65,29,1970 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 2100 ug/kg SEX/DURATION : female 15-19 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - behavioral REFERENCE : JDPHDH Journal of Developmental Physiology. (Oxford University Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1979- Volume(issue)/page/year: 19,67,1993 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular DOSE : 4500 ug/kg SEX/DURATION : female 15-19 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - biochemical and metabolic REFERENCE : GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 26,365,1995

合成路线

3052-45-7 ~% 432-60-0

文献：de Winter et al. Chemistry and Industry (London, United Kingdom), 1959 , p. 905

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