2322-77-2

• 常用中文名：沃氏物
• 常用英文名：Methoxydienone
• CAS号：2322-77-2
• 分子式：C₂₀H₂₈O₂
• 分子量：300.435
• 发布时间：2018-09-03 17:42:30
• 更新时间：2026-07-01 09:02:02
• 【用途一】
  18-甲基炔诺酮、三烯高诺酮的中间体。

名称

• 中文名: 沃氏物
• 英文名: Methoxydienone
• 中文别名: D-沃氏物; 基－2,5(10)雌甾二烯－17－酮; 18-甲基-3-甲氧基-2,5雌甾二烯-17-酮; 1,3-二乙基-3Β-甲氧基腺甾-2,5-二烯-17-酮; 乙基沃氏物(左炔中间体); 左炔诺孕酮中间体/沃氏物; 18-甲基雌甾-2,5(10)-二烯-3b-甲氧基-17-酮; 群勃龙庚酸; 13Β-乙基-D-甲氧基-2,5-GONADIEN-17-ONE; 基－2,5雌甾二烯－17－酮; 18-甲基雌甾-2,5-二烯-3b-甲氧基-17-酮; 乙基沃氏物; 左炔诺孕酮杂质R; 8-甲基雌甾-2,5-二烯-3B-甲氧基-17-酮; 沃氏物(甾体); 左炔诺孕酮杂质18(左炔诺孕酮杂质R); 沃氏物/左炔诺孕酮杂质R; 18－甲基－3－甲氧; 群勃龙庚酸脂; 1,3-二乙基-3Β-甲氧基腺甾-2,5(10)-二烯-17-酮; 左炔诺孕酮中间体
• 英文别名: 18-Methylestra-2,5-dien-3-ol-17-one-3-methy ether; (13S)-13β-Ethyl-3-methoxygona-2,5-dien-17-one; Levonorgestrel impurity R; 13-beta-Ethyl-3-methoxy; METHOXYDIENONE(13-BETA-ETHYL-3-METHOXYGONA-2,5-DIEN-17-ONE); Levonorgestrel Impurity RQ: What is Levonorgestrel Impurity R Q: What is the CAS Number of Levonorgestrel Impurity R Q: What is the storage condition of Levonorgestrel Impurity R Q: What e the applications of Levonorgestrel Impurity R; 13-beta-Ethyl-3-methoxygona-2,5-dien-17-one; D(-)-18-METHYL-3-METHOXY-ESTRA-2,5-DIEN-17-ONE; Trenbolone Enanthate CAS NO.2-2; MFCD08457893; 3-Methoxy-18-methylestra-2,5-dien-17-one; METHOXYDIENONE; 16α,17α-oxy-3-oxoandrost-4-en-21-oicacidγ-lactone; Methoxygonadiene; 13-Ethyl-3-methoxy-gona-2,5(10; Methoxydienone, maximum LMG; Methoxydienone Prohormone Raw Powder; Levonorgestrel Impurity ‘R’; (8R,9S,13S,14S)-13-Ethyl-3-methoxy-1,4,6,7,8,9,11,12,13,14,15,16-dodecahydro-17H-cyclopenta[a]phenanthren-17-one; Levonorgestrel Impurity 18（Levonorgestrel Impurity R）; 3-methoxy-17-dehydro-18-methyl-19-nor-δ2,5-testosterone; 13-β-ethyl-3-methoxygona-2,5-dien-17-one; 13-ethyl-3-methoxy-4,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-one; 13β-Ethyl-d-methoxy-2,5-gonadien-17-one; Finished Injectable Steroids Oil; EINECS 219-034-4; Wueste Substance; 13-ethyl-3-methoxy-gona-2,5-dien-17-one (Methoxydienone; Methoxydienone Max LMG; 13-ETHYL-3-METHOXY-GONA-2,5-DIEN-17-ONE; Gona-2,5-dien-17-one,13-ethyl-3-Methoxy; Methoxygonadiene D5; (8r,9s,13s,14s)-13-ethyl-3-methoxy-4,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-17-one; 13-β-Ethyl-3-methoxy-gona-2,5-dien-17-one/Methoxydienone; 3-Mehoxy-18-Methyestra-2,5-dien-17-one; na-2,5-dien-17-one; Tren base

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 448.0±45.0 °C at 760 mmHg
• 熔点: ≥170ºC
• 分子式: C₂₀H₂₈O₂
• 分子量: 300.435
• 闪点: 188.8±22.3 °C
• 精确质量: 300.208923
• PSA: 26.30000
• LogP: 4.31
• 外观性状: 白色结晶粉末
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.551
• 储存条件: 2-8℃，干燥

合成路线

14507-49-4 ~85% 2322-77-2

文献：Lui, Li-Gong; Zhang, Tong; Li, Zhen-Su Synthetic Communications, 1996 , vol. 26, # 16 p. 2999 - 3006

14507-49-4 555-31-7 7757-82-6 ~% 2322-77-2

文献：US3959322 A1, ;

2911-81-1 ~% 2322-77-2

文献：Justus Liebigs Annalen der Chemie, , vol. 702, p. 141 - 148

7443-72-3 ~% 2322-77-2

文献：Synthetic Communications, , vol. 26, # 16 p. 2999 - 3006

75863-25-1 ~% 2322-77-2

文献：Helvetica Chimica Acta, , vol. 68, # 4 p. 1054 - 1068

101025-85-8 ~% 2322-77-2

文献：Helvetica Chimica Acta, , vol. 68, # 4 p. 1054 - 1068

14507-47-2 ~% 2322-77-2

文献：Justus Liebigs Annalen der Chemie, , vol. 702, p. 141 - 148

上下游产品

上游产品  6
14507-49-4 555-31-7 7757-82-6 2911-81-1
7443-72-3 75863-25-1
下游产品  4
4222-96-2 797-63-7 21800-83-9 20799-05-7

制备

【方法一】
用3-甲氧基-18-甲基-1,3,5（10）,8-雌甾四烯-17-酮先后以钾硼氢、锂-氨还原，生成3-甲氧基-18-甲基2,5（10）雌甾二烯-17-醇，然后以环己酮-异丙醇铝氧化（沃氏氧化）制得该品。