316149-01-6

• 常用中文名：5-氯-6'-甲基-3-[4-(甲基亚磺酰基)苯基]-2,3'-联吡啶
• 常用英文名：5-Chloro-6'-methyl-3-[4-(methylsulfinyl)phenyl]-2,3'-bipyridine
• CAS号：316149-01-6
• 分子式：C₁₈H₁₅ClN₂OS
• 分子量：342.84300
• 发布时间：2019-01-12 09:55:47
• 更新时间：2026-07-15 17:37:03

名称

• 中文名: 5-氯-6'-甲基-3-[4-(甲基亚磺酰基)苯基]-2,3'-联吡啶
• 英文名: 5-chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfinylphenyl)pyridine
• 中文别名: 依托考昔亚砜杂质; 5-氯-6'-甲基-3-(4-(甲基亚磺酰基)苯基)-2,3'-联吡啶(依托考昔杂质); 依托考昔11; 依托考昔杂质A; 依托昔布杂质B; 依托度昔布杂质B
• 英文别名: Etoricoxib A; Etoricoxib Sulfoxide; Etoricoxib impurity 1/5-chloro-6'-methyl-3-(4-(methylsulfinyl)phenyl)-2,3'-bipyridine; 5-Chloro-6'-methyl-3-(4-(methylsulfinyl)phenyl)-2,3'-bipyridine (Etoricoxib Impurity); Etoricoxib Impurity 10; Etocoxib impurity 3; 2,3'-Bipyridine, 5-chloro-6'-methyl-3-[4-(methylsulfinyl)phenyl]; Etoricoxib Impurity B; Etoricoxib Impurity 2; IMpurity of Etoricoxib

物化性质

• 密度: 1.37±0.1 g/cm3
• 熔点: 122-123 ºC
• 分子式: C₁₈H₁₅ClN₂OS
• 分子量: 342.84300
• 精确质量: 342.05900
• PSA: 62.06000
• LogP: 5.37550
• 储存条件: 室温

合成路线

292067-97-1 ~86% 316149-01-6

文献：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK Patent: WO2005/120584 A2, 2005 ; Location in patent: Page/Page column 34-35 ;

745050-29-7 ~% 316149-01-6

文献：Caturla, Francisco; Amat, Merce; Reinoso, Raquel F.; Cordoba, Monica; Warrellow, Graham Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 12 p. 3209 - 3212

745050-30-0 ~% 316149-01-6

文献：Caturla, Francisco; Amat, Merce; Reinoso, Raquel F.; Cordoba, Monica; Warrellow, Graham Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 12 p. 3209 - 3212

745050-28-6 ~% 316149-01-6

文献：Caturla, Francisco; Amat, Merce; Reinoso, Raquel F.; Cordoba, Monica; Warrellow, Graham Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 12 p. 3209 - 3212

221615-72-1 ~% 316149-01-6

文献：Majo, Vattoly J.; Prabhakaran, Jaya; Simpson, Norman R.; Van Heertum, Ronald L.; Mann, J. John; Kumar, J. S. Dileep Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 19 p. 4268 - 4271

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