46868-19-3

• 常用中文名：N-Desmethylnefopam
• 常用英文名：N-Desmethylnefopam
• CAS号：46868-19-3
• 分子式：C₁₆H₁₇NO
• 分子量：239.31200
• 相关类别： 研究领域 神经疾病
• 发布时间：2017-10-23 10:06:10
• 更新时间：2024-01-02 20:59:33
• N-Desmethylnefopam 是 Nefopam 的主要代谢产物,是一种中枢性但非阿片类镇痛药,可缓解中度至重度疼痛。Nefopam 作用于体外和体内间充质细胞 β-连环蛋白水平。

名称

• 英文名: 1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine
• 英文别名: desmethyl nefopam; nor-nefopam; 1H-2,5-Benzoxazocine,3,4,5,6-tetrahydro-1-phenyl

物化性质

• 密度: 1.073g/cm3
• 沸点: 383.4ºC at 760 mmHg
• 分子式: C₁₆H₁₇NO
• 分子量: 239.31200
• 闪点: 157.1ºC
• 精确质量: 239.13100
• PSA: 21.26000
• LogP: 3.22460
• 折射率: 1.563

生物活性

• 描述: N-Desmethylnefopam 是 Nefopam 的主要代谢产物,是一种中枢性但非阿片类镇痛药,可缓解中度至重度疼痛。Nefopam 作用于体外和体内间充质细胞 β-连环蛋白水平。
• 相关类别:
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Mittur A. A Simultaneous Mixed-Effects Pharmacokinetic Model for Nefopam, N-desmethylnefopam, and Nefopam N-Oxide in Human Plasma and Urine. Eur J Drug Metab Pharmacokinet. 2018 Aug;43(4):391-404.

  [2]. Kim KH, et al. Rediscovery of nefopam for the treatment of neuropathic pain. Korean J Pain. 2014 Apr;27(2):103-11.

  [3]. Baht GS, et al. Pharmacologically targeting beta-catenin for NF1 associated deficiencies in fracture repair. Bone. 2017 May;98:31-36.

合成路线

47205-41-4 ~85% 46868-19-3

文献：Rosamilia, Anthony E.; Mayes, Penelope A.; Papadopoulos, Roslyn; Campi, Eva M.; Jackson, W. Roy; Rash, Lachlan; Jarrott, Bevyn Australian Journal of Chemistry, 2002 , vol. 55, # 9 p. 577 - 585

84940-28-3 ~10% 46868-19-3

文献：Rosamilia, Anthony E.; Mayes, Penelope A.; Papadopoulos, Roslyn; Campi, Eva M.; Jackson, W. Roy; Rash, Lachlan; Jarrott, Bevyn Australian Journal of Chemistry, 2002 , vol. 55, # 9 p. 577 - 585

147678-38-4 ~% 46868-19-3

文献：Glaser; Geresh; Blumenfeld; Donnell; Sugisaka; Drouin; Michel Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 3 p. 276 - 281

65184-67-0 ~% 46868-19-3

文献：Glaser; Geresh; Blumenfeld; Donnell; Sugisaka; Drouin; Michel Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 3 p. 276 - 281

643-79-8 ~% 46868-19-3

文献：Glaser; Geresh; Blumenfeld; Donnell; Sugisaka; Drouin; Michel Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 3 p. 276 - 281

13678-15-4 ~% 46868-19-3

文献：Glaser; Geresh; Blumenfeld; Donnell; Sugisaka; Drouin; Michel Journal of Pharmaceutical Sciences, 1993 , vol. 82, # 3 p. 276 - 281

85-52-9 ~% 46868-19-3

文献：Rosamilia, Anthony E.; Mayes, Penelope A.; Papadopoulos, Roslyn; Campi, Eva M.; Jackson, W. Roy; Rash, Lachlan; Jarrott, Bevyn Australian Journal of Chemistry, 2002 , vol. 55, # 9 p. 577 - 585

18409-76-2 ~% 46868-19-3

文献：Rosamilia, Anthony E.; Mayes, Penelope A.; Papadopoulos, Roslyn; Campi, Eva M.; Jackson, W. Roy; Rash, Lachlan; Jarrott, Bevyn Australian Journal of Chemistry, 2002 , vol. 55, # 9 p. 577 - 585

上下游产品

上游产品  7
84940-28-3 147678-38-4 65184-67-0 643-79-8
13678-15-4 85-52-9 18409-76-2
下游产品  2
18409-76-2 868693-39-4