94593-91-6

• 常用中文名：醚黄隆
• 常用英文名：cinosulfuron
• CAS号：94593-91-6
• 分子式：C₁₅H₁₉N₅O₇S
• 分子量：413.40600
• 相关类别： 化学农药原药 除草剂 取代脲类除草剂
• 发布时间：2018-07-22 15:05:37
• 更新时间：2024-01-05 09:59:51
• 【用途一】
  磺酰脲类除草剂，通过阻碍缬氨酸及异亮氨酸合成，从而抑制细胞分裂及细胞的长大。用药手生长停止，5～10d植株开始黄化、枯萎、死亡。可用于插秧稻、直播稻及秧田，防除一年生阔叶杂草及莎草科杂草。用于插秧田在水稻插秧后4～7d用20%水分散粒剂90～150g/hm² (有效成分18～30g)，进行叶茎喷雾或撒毒土（沙）处理，处理后保持田水3～5d，防除鸭舌草、节节菜、萤蔺、眼子菜、牛毛毡、三雄沟繁缕。用于直播田，在水稻播种后7～15d，用20%水分散粒剂90～150g/hm² (有效成分18～30g)进行撒毒土或喷雾，处理后保持田水3～5d。醚磺隆还可用于可可、橡胶、棕榈园中防除一般杂草和蕨类杂草。

名称

• 中文名: 醚磺隆
• 英文名: cinosulfuron
• 中文别名: 醚黄隆; 莎多伏; 醚菌酯; 1-(4,6-二甲氧基-1,3,5-三嗪-2-基)-3-[2(2-甲氧基乙氧基)苯基磺酰]脲
• 英文别名: N-[[(4,6-dimethoxy-1,3,5-triazin-2-yl)amino]carbonyl]-2-(2-methoxyethoxy)benzenesulfonamide; N-[2-(2-methoxyethoxy)-phenylsulphonyl]-N'-(4,6-dimethoxy-1,3,5-triazin-2-yl)-urea; Cinosulfuron [ISO]; 1-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-3-(2-(2-methoxyethoxy)phenylsulfonyl)urea (IUPAC); 1-(4,6-dimethoxy-1,3,5-triazin-2-yl)-3-[2-(2-methoxyethoxy)phenyl]sulfonylurea; N-[(4,6-dimethoxy-1,3,5-triazin-2-yl)carbamoyl]-2-(2-methoxyethoxy)benzene-1-sulfonamide; 3-(4,6-dimethoxy-1,3,5-triazin-2-yl)-1-[2-(2-methoxyethoxy)-phenylsulphonyl]urea; Cinosulfuron; 1-(4,6-dimethoxy-1,3,5-triazin-2-yl)-3-[2-(2-methoxyethoxy)phenylsulfonyl]urea; MFCD01311813; Benzenesulfonamide,N-(((4,6-dimethoxy-1,3,5-triazin-2-yl)amino)carbonyl)-2-(2-methoxyethoxy); N-(2-methoxyethoxy-phenylsulfonyl)-N'-(4,6-dimethoxy-1,3,5-triazin-2-yl)-urea; N-[2-(2-methoxyethoxy)-phenylsulfonyl]-N'-(4,6-bis-methoxy-1,3,5-triazin-2-yl)-urea

物化性质

• 密度: 1.415 g/cm3
• 熔点: 140-145°C
• 分子式: C₁₅H₁₉N₅O₇S
• 分子量: 413.40600
• 闪点: 144 °C
• 精确质量: 413.10100
• PSA: 159.24000
• LogP: 1.96910
• 外观性状: 无色结晶粉末
• 折射率: 1.57
• 储存条件:

  密封储存，储存于阴凉、干燥的库房。

• 稳定性:

  常温常压下稳定，避免与强氧化剂接触。对兔眼睛和皮肤无刺激作用。对豚鼠无致敏性。在试验条件下无致畸、致癌、致突变作用。

• 计算化学:

  1.疏水参数计算参考值（XlogP）:1.4

  2.氢键供体数量:2

  3.氢键受体数量:10

  4.可旋转化学键数量:9

  5.互变异构体数量:7

  6.拓扑分子极性表面积159

  7.重原子数量:28

  8.表面电荷:0

  9.复杂度:576

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：无色结晶固体。

  2. 密度（g/mL,25℃）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：144.6

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC，13mmHg）：未确定

  7. 折射率(n20/D)：未确定

  8. 闪点（ºC）：144

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（mmHg,20ºC）：1×10^-10

  12. 饱和蒸气压（kPa,25ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：不溶于水

毒性和生态

毒理学数据: 1、急性毒性：大鼠经口LD50：>10368mg/kg；大鼠吸入LC50：>5574 mg/m3/4H； 大鼠皮肤接触LD50：>5mg/kg；小鼠经口LD50：>10368/kg；鹌鹑经口LD50：>2mg/kg； 2、其他多剂量毒性：大鼠经口TDLo：81081 mg/kg/13W-C；大鼠经口TDLo：400 mg/kg/2Y-C；小鼠经口TDLo：328 mg/kg/2W-C；小鼠经口TDLo：1310mg/kg/2Y-C；狗经口TDLo：155 mg/kg/1Y-C； CHEMICAL IDENTIFICATION RTECS NUMBER : DB2070000 CHEMICAL NAME : Benzenesulfonamide, N-(((4,6-dimethoxy-1,3,5-triazin-2-yl)amino)carbonyl) -2-(2-methoxyethoxy)- CAS REGISTRY NUMBER : 94593-91-6 LAST UPDATED : 199710 DATA ITEMS CITED : 11 MOLECULAR FORMULA : C15-H19-N5-O7-S MOLECULAR WEIGHT : 413.45 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >10368 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S165,1992 TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5574 mg/m3/4H TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S165,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,174,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >10368 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S165,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - quail DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,174,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 81081 mg/kg/13W-C TOXIC EFFECTS : Kidney, Ureter, Bladder - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S165,1992 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 400 gm/kg/2Y-C TOXIC EFFECTS : Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S165,1992 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 328 gm/kg/13W-C TOXIC EFFECTS : Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S165,1992 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1310 gm/kg/2Y-C TOXIC EFFECTS : Brain and Coverings - changes in brain weight Kidney, Ureter, Bladder - changes in bladder weight Related to Chronic Data - changes in testicular weight REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S165,1992 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 155 gm/kg/1Y-C TOXIC EFFECTS : Liver - changes in liver weight Endocrine - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 17,S165,1992

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport
• RTECS号: DB2070000

制备

2-甲氧乙氧基苯磺酰胺的制备 由溴苄依次与2-氯苯磺酰胺、乙二醇单甲醚反应，然后水解得2-甲氧乙氧基苯磺酰胺。
2-甲氧乙氧基苯磺酰基异氰酸酯的制备 由2-甲氧乙氧基苯磺酰胺依次与异氰酸甲酯、光气作用，制得2-甲氧乙氧基苯磺酰基异氰酸酯。
3.醚磺隆的合成 2-氨基-4，6-二甲氧基-1，3，5-三嗪与2-甲氧乙氧基苯磺酰基异氰酸酯作用制得醚磺隆。