114676-97-0

• 常用中文名：(2R,4R)-N-Boc-2-氟甲基-4-羟基吡咯烷
• 常用英文名：(2R,4R)-n-Boc-2-(Fluoromethyl)-4-hydroxypyrrolidine
• CAS号：114676-97-0
• 分子式：C₁₀H₁₈FNO₃
• 分子量：219.25300
• 发布时间：2018-12-11 15:24:04
• 更新时间：2026-07-14 09:27:42

名称

• 中文名: (2R,4R)-N-Boc-2-氟甲基-4-羟基吡咯烷
• 英文名: tert-butyl (2R,4R)-2-(fluoromethyl)-4-hydroxypyrrolidine-1-carboxylate
• 中文别名: (2R,4R)-2-(氟甲基)-4-羟基吡咯烷-1-羧酸叔丁酯; (2R,4R)-2-氟甲基-4-羟基吡咯烷-1-甲酸叔丁酯
• 英文别名: tert-butyl (2R,4R)-2-(fluoromethyl)-4-hydroxypyrrolidine-1-cboxylate; (2R,4R)-tert-Butyl 2-(fluoromethyl)-4-hydroxypyrrolidine-1-cboxylate; (2R-cis)-2-(Fluoromethyl)-4-hydroxy-1-pyrrolidinecboxylic acid 1,1-dimethylethyl ester; (2R-cis)-2-(Fluoromethyl)-4-hydroxy-pyrrolidine-1-cboxylic acid tert-butyl ester; (2r,4r)-n-boc-2-(fluoromethyl)-4-hydroxypyrrolidine; tert-butyl 2-(fluoroMethyl)-4-hydroxypyrrolidine-1-cboxylate; 1-Pyrrolidinecboxylic acid, 2-(fluoromethyl)-4-hydroxy-, 1,1-dimethylethyl ester, (2R-cis)- (9CI)

物化性质

• 密度: 1.151
• 沸点: 302.7ºC at 760 mmHg
• 熔点: 98-99ºC
• 分子式: C₁₀H₁₈FNO₃
• 分子量: 219.25300
• 精确质量: 219.12700
• PSA: 49.77000
• LogP: 1.26410
• 折射率: 1.471

合成路线

114676-75-4 ~59% 114676-97-0

文献：Rosen, Terry; Chu, Daniel T. W.; Lico, Isabella M.; Fernandes, Prabhavathi B.; Marsh, Kennan; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 8 p. 1598 - 1611

24424-99-5 ~% 114676-97-0

文献：Journal of Medicinal Chemistry, , vol. 31, # 8 p. 1598 - 1611

114676-69-6 ~% 114676-97-0

文献：Journal of Medicinal Chemistry, , vol. 31, # 8 p. 1598 - 1611

114676-59-4 ~% 114676-97-0

文献：Journal of Medicinal Chemistry, , vol. 31, # 8 p. 1598 - 1611

114676-74-3 ~% 114676-97-0

文献：Journal of Medicinal Chemistry, , vol. 31, # 8 p. 1598 - 1611

114677-05-3 ~% 114676-97-0

文献：Journal of Medicinal Chemistry, , vol. 31, # 8 p. 1598 - 1611

2584-71-6 ~% 114676-97-0

文献：Journal of Medicinal Chemistry, , vol. 31, # 8 p. 1598 - 1611

上下游产品

上游产品  7
114676-75-4 24424-99-5 114676-69-6 114676-59-4
114676-74-3 114677-05-3 2584-71-6
下游产品  0