86-40-8

• 常用中文名：氯代3,6-二氨基-10-甲基吖啶
• 常用英文名：Acriflavinium chloride
• CAS号：86-40-8
• 分子式：C₁₄H₁₄ClN₃
• 分子量：259.734
• 发布时间：2018-08-01 13:15:05
• 更新时间：2024-01-08 08:51:14

• 用作消毒剂，并有杀灭昏睡病锥虫的作用。

名称

• 中文名: 氯代3,6-二氨基-10-甲基吖啶
• 英文名: 3,6-diamino-10-methylacridinium chloride
• 英文别名: EINECS 201-668-8; MFCD00011760; 3,6-diamino-10-methyl-acridiniuchloride; acriflavinium hydrochloride; Acriflavinium chloride; Acriflavon; burnol; Acridinium,3,6-diamino-10-methyl-,chloride; 3,6-diamino-10-methyl-acridinium chloride; Neutroflavine; Acridinium, 3,6-diamino-10-methyl-, chloride (1:1); 3,6-Diamino-10-methylacridinium chloride; 2 8-DIAMINO-10-METHYLACRIDINIUM CHLORIDE HYDROCHLORIDE; ACRIDINIUM, 3,6-DIAMINO-10-METHYL-, CHLORIDE; Acriflavine (component of); trypaflavine; Avlon; CHROMOFLAVINE

物化性质

• 分子式: C₁₄H₁₄ClN₃
• 分子量: 259.734
• 精确质量: 259.087616
• PSA: 55.92000
• LogP: 0.14830
• 储存条件:

  密封保存。

• 计算化学:

  1、 氢键供体数量：2

  2、 氢键受体数量：3

  3、 可旋转化学键数量：0

  4、 互变异构体数量：2

  5、 拓扑分子极性表面积（TPSA）：55.9

  6、 重原子数量：18

  7、 表面电荷：0

  8、 复杂度：255

  9、 同位素原子数量：0

  10、 确定原子立构中心数量：0

  11、 不确定原子立构中心数量：0

  12、 确定化学键立构中心数量：0

  13、 不确定化学键立构中心数量：0

  14、 共价键单元数量：2

• 更多:

  1. 性状：红色针状晶体

  2. 密度（g/mL,25/4℃）：未确定

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：未确定

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：溶于水及乙醇，稀水溶液呈黄色并带绿色荧光

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AR9625000 CHEMICAL NAME : Acridinium, 3,6-diamino-10-methyl-, chloride CAS REGISTRY NUMBER : 86-40-8 LAST UPDATED : 199806 DATA ITEMS CITED : 42 MOLECULAR FORMULA : C14-H14-N3.Cl MOLECULAR WEIGHT : 259.76 WISWESSER LINE NOTATION : T C666 BKJ B1 EZ MZ &Q &G HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human DOSE/DURATION : 1500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 11 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 14 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 40 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : 7353 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - other changes TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 40 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - quail DOSE/DURATION : >100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Amphibian - frog DOSE/DURATION : 800 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Cardiac - other changes Lungs, Thorax, or Respiration - other changes TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 65 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - wild bird species DOSE/DURATION : 56200 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : Micronucleus test TYPE OF TEST : Cytogenetic analysis TYPE OF TEST : Dominant lethal test TYPE OF TEST : Sperm Morphology MUTATION DATA TYPE OF TEST : DNA adduct TEST SYSTEM : Mammal - species unspecified Lymphocyte DOSE/DURATION : 10 pph REFERENCE : BIPMAA Biopolymers. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1963- Volume(issue)/page/year: 11,2537,1972 *** REVIEWS *** TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975

安全

• 海关编码: 2933990090

合成路线

15724-70-6 ~% 86-40-8

文献：Ishifuku; Ito Yakugaku Zasshi, 1929 , vol. 49, p. japan. Teil, S. 748 Chem.Abstr., 1930 , vol. 14, p. 118 Full Text Show Details Browning et al. Pr. roy. Soc. , vol. 93, p. 350 Chem. Zentralbl., 1922 , vol. 93, # III p. 742

上下游产品

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15724-70-6
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海关

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%