28752-91-2

• 常用中文名：1H-Indene-1,3(2H)-dione,2-[(dimethylamino)methylene]-
• 常用英文名：1H-Indene-1,3(2H)-dione,2-[(dimethylamino)methylene]-
• CAS号：28752-91-2
• 分子式：C₁₂H₁₁NO₂
• 分子量：201.22100
• 发布时间：2017-07-20 16:31:20
• 更新时间：2024-01-30 22:04:52

名称

• 英文名: 2-(dimethylaminomethylidene)indene-1,3-dione
• 英文别名: 2-dimethylaminomethylene-1,3-indandione; 2-dimethylaminomethyleneindane-1,3-dione; 2-Dimethylaminomethyliden-1,3-indandion; Dimethylaminomethylene-2 indanedione-1,3 [French]; COR 3761; 2-Dimethylaminomethylen-1,3-indandion; 2-[(dimethylamino)methylene]-1H-indene-1,3(2H)-dione; 1H-indene-1,3(2H)-dione,2-[(dimethylamino)methylene]; 1,3-Indandione,2-((dimethylamino)methylene); 2-dimethylaminomethylene-1,3-indendione

物化性质

• 密度: 1.319g/cm3
• 沸点: 324.7ºC at 760 mmHg
• 分子式: C₁₂H₁₁NO₂
• 分子量: 201.22100
• 闪点: 142.6ºC
• 精确质量: 201.07900
• PSA: 37.38000
• LogP: 1.51110
• 蒸汽压: 0.000242mmHg at 25°C
• 折射率: 1.684

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : NK8390355 CHEMICAL NAME : 1H-Indene-1,3(2H)-dione, 2-((dimethylamino)methylene)- CAS REGISTRY NUMBER : 28752-91-2 LAST UPDATED : 199701 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C12-H11-N-O2 MOLECULAR WEIGHT : 201.24 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 520 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : EPXXDW European Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0172128 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 440 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness Nutritional and Gross Metabolic - body temperature decrease REFERENCE : PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 10,320,1976

合成路线

606-23-5 4637-24-5 ~82% 28752-91-2

文献：Schenone, Pietro; Mosti, Luisa; Menozzi, Giulia Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1355 - 1361

81066-47-9 124-40-3 ~49% 28752-91-2

文献：Hanefeld; Kluck Archiv der Pharmazie, 1982 , vol. 315, # 1 p. 68 - 78

81054-58-2 ~% 28752-91-2

文献：Hanefeld; Kluck Archiv der Pharmazie, 1982 , vol. 315, # 1 p. 68 - 78

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