6829-98-7

• 常用中文名：氧丙咪嗪
• 常用英文名：3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine oxide
• CAS号：6829-98-7
• 分子式：C₁₉H₂₄N₂O
• 分子量：296.40700
• 相关类别： 研究领域 神经疾病
• 发布时间：2018-03-18 08:00:00
• 更新时间：2026-07-14 15:46:43
• 氧化丙咪嗪是丙咪嗪的代谢产物。丙咪嗪是一种叔胺三环抗抑郁剂[1][2]。

名称

• 中文名: 氧丙咪嗪
• 英文名: 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N-dimethylpropan-1-amine oxide
• 中文别名: 丙咪嗪氮氧化物 标准品; 丙咪嗪杂质12; 丙咪嗪N-氧化物; 盐酸丙咪嗪杂质12; 氧米帕明
• 英文别名: Imipramine oxide; imipramine N oxide; Imipraminoxide; N,N-Dimethyl 10,11-dihydro-5H-dibenz[b,f]azine 5-propan-1-amine N-oxide; UNII-8MKS280XJW; Imipramine N-Oxide Monohydrate; 5-[3-(Dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azine 5-oxide Monohydrate; Einecs -1; 3-(5,6-dihydrobenzo[b]benzazin-11-yl)-N,N-dimethylpropan-1-amine oxide; 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azine-5-propan-1-amine oxide; 5-(3-(Dimethylamino)propyl)-10,11-dihydro-5H-dibenz(B,F)azine N-oxide; Elsin; 5H-Dibenzb,fazine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, N-oxide; 10,11-Dihydro-N,N-dimethyl-5H-dibenz(B,F)azine-5-propanamine N-oxide; Imipraminoxide Monohydrate; Imipraminoxidum; 10,11-Dihydro-N,N-diMethyl; 5H-Dibenz(B,F)azine, 5-(3-(dimethylamino)propyl)-10,11-dihydro-, N-oxide; 5-(3-(Dimethylamino)propyl)-10,11-dihydro-5H-dibenz(B,F)azine 5-oxide; 19-2 (Hydrochloride); 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azine-5-propanamine N-Oxide Monohydrate; Elepsin; Imipramine hydrochloride Impurity 12; Imipraminoxido

物化性质

• 熔点: 93-95ºC
• 分子式: C₁₉H₂₄N₂O
• 分子量: 296.40700
• 精确质量: 296.18900
• PSA: 32.67000
• LogP: 3.97350

生物活性

• 描述: 氧化丙咪嗪是丙咪嗪的代谢产物。丙咪嗪是一种叔胺三环抗抑郁剂[1][2]。
• 相关类别:
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Bickel MH, et al. Metabolic interconversions between imipramine, its N-oxide, and its desmethyl derivative in rat tissues in vitro. Biochem Biophys Res Commun. 1968;33(6):1012-1018.

  [2]. Fayez R, et al. Imipramine. [Updated 2021 Nov 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-.

安全

• 危险品运输编码: UN 3249
• 包装等级: III
• 危险类别: 6.1(b)

合成路线

50-49-7 ~% 6829-98-7

文献：Tetrahedron Letters, , vol. 51, # 43 p. 5690 - 5693

113-52-0 ~% 494-19-9 6829-98-7

文献：Hufford; Capiton; Clark; Baker Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 2 p. 151 - 155

113-52-0 ~% 494-19-9 796-28-1 303-70-8 详细

文献：Journal of Pharmaceutical Sciences, , vol. 70, # 2 p. 151 - 155

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