499-67-2

• 常用中文名：丙美卡因
• 常用英文名：proxymetacaine
• CAS号：499-67-2
• 分子式：C₁₆H₂₆N₂O₃
• 分子量：294.38900
• 相关类别： 原料药 Anesthetic Agents Local anesthetics
• 发布时间：2018-04-24 08:00:00
• 更新时间：2025-09-12 09:03:28

名称

• 中文名: 丙美卡因
• 英文名: Proparacaine Hydrochloride
• 英文别名: 2-(diethylamino)ethyl 3-amino-4-propoxybenzoate

物化性质

• 密度: 1.065 g/cm3
• 沸点: 434.4ºC at 760 mmHg
• 熔点: 182-183.30C
• 分子式: C₁₆H₂₆N₂O₃
• 分子量: 294.38900
• 闪点: 216.5ºC
• 精确质量: 294.19400
• PSA: 64.79000
• LogP: 3.13740
• 蒸汽压: 9.5E-08mmHg at 25°C
• 折射率: 1.527
• 储存条件: Refrigerator

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DG3058000 CHEMICAL NAME : Benzoic acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl ester CAS REGISTRY NUMBER : 499-67-2 BEILSTEIN REFERENCE NO. : 2745891 LAST UPDATED : 199709 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C16-H26-N2-O3 MOLECULAR WEIGHT : 294.44 WISWESSER LINE NOTATION : 3OR BZ DVO2N2&2 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4800 ug/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 63,369,1938 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0782 No. of Facilities: 5 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 14 (estimated)

合成路线

736870-51-2 ~% 499-67-2

文献：Clinton et al. Journal of the American Chemical Society, 1952 , vol. 74, p. 592,595

616-82-0 ~% 499-67-2

文献：Clinton et al. Journal of the American Chemical Society, 1952 , vol. 74, p. 592,595

35288-44-9 ~% 499-67-2

文献：Clinton et al. Journal of the American Chemical Society, 1952 , vol. 74, p. 592,595

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