CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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GH0910000
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CHEMICAL NAME :
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Colchicine, 17,17,17-trifluoro-
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CAS REGISTRY NUMBER :
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26195-65-3
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LAST UPDATED :
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199612
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DATA ITEMS CITED :
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2
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MOLECULAR FORMULA :
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C22-H22-F3-N-O6
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MOLECULAR WEIGHT :
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453.45
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WISWESSER LINE NOTATION :
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L B677 MV&T&J CO1 DO1 EO1 JMVXFFF NO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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844 mg/kg
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TOXIC EFFECTS :
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Tumorigenic - active as anti-cancer agent
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REFERENCE :
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JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,636,1981
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intramuscular
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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456 ug/kg
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TOXIC EFFECTS :
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Nutritional and Gross Metabolic - weight loss or decreased weight gain
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REFERENCE :
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JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,257,1981
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