952188-00-0

• 常用中文名：N-[乙基-(2-吡啶基-5-乙基)吡格列酮(吡格列酮杂质)
• 常用英文名：N-[Ethyl-(2-pyridyl-5-ethyl) Pioglitazone
• CAS号：952188-00-0
• 分子式：C₂₈H₃₁N₃O₃S
• 分子量：489.62900
• 发布时间：2016-03-12 05:26:39
• 更新时间：2024-01-05 17:39:46

名称

• 中文名: 吡格列酮杂质C (EP)
• 英文名: 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-3-[2-(5-ethylpyridin-2-yl)ethyl]-1,3-thiazolidine-2,4-dione
• 中文别名: N-乙基(2-吡啶基-5-乙基)吡格列酮; 5-[4-[2-(5-乙基吡啶-2-基)乙氧基]苄基]-3-[2-(5-乙基吡啶-2-基)乙基]噻唑烷-2,4-二酮
• 英文别名: UNII-0A40W8CWPF; Pioglitazone hydrochloride specified impurity C [EP]; Pioglitazone hydrochloride impurity,N-alkylpioglitazone-[USP]; 5-{4-[2-(5-ethyl-pyridin-2-yl)ethoxy]benzyl}-3-[2-(5-ethyl-pyridin-2-yl)ethyl]-1,3-thiazolidine-2,4-dione; N-(Ethyl-(2-pyridyl-5-ethyl)) pioglitazone; (+/-)-5-(4-(2-(5-Ethylpyridin-2-yl)ethoxy)benzyl)-3-(2-(5-ethylpyridin-2-yl)ethyl)thiazolidine-2,4-dione; N-[Ethyl-(2-pyridyl-5-ethyl) Pioglitazone(Pioglitazone Impurity); N-[Ethyl-(2-pyridyl-5-ethyl) Pioglitazone; 5-[4-[2-(5-Ethylpyridin-2-yl)ethoxy]benzyl]-3-[2-(5-ethylpyridin-2-yl)ethyl]thiazolidine-2,4-dione; Pioglitazone Impurity 3

物化性质

• 密度: 1.217g/cm3
• 沸点: 663.3ºC at 760 mmHg
• 熔点: 93 ºC
• 分子式: C₂₈H₃₁N₃O₃S
• 分子量: 489.62900
• 闪点: 354.9ºC
• 精确质量: 489.20900
• PSA: 97.69000
• LogP: 5.01000
• 折射率: 1.612

合成路线

105355-27-9 144809-27-8 ~51% 952188-00-0 16106-44-8

文献：Richter, Jindrich; Jirman; Havlicek; Hrdina Pharmazie, 2007 , vol. 62, # 8 p. 580 - 584

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