952188-00-0

• 常用中文名：N-[乙基-(2-吡啶基-5-乙基)吡格列酮(吡格列酮杂质)
• 常用英文名：N-[Ethyl-(2-pyridyl-5-ethyl) Pioglitazone
• CAS号：952188-00-0
• 分子式：C₂₈H₃₁N₃O₃S
• 分子量：489.62900
• 发布时间：2016-03-12 05:26:39
• 更新时间：2026-07-06 16:36:31

名称

• 中文名: 吡格列酮杂质C (EP)
• 英文名: 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-3-[2-(5-ethylpyridin-2-yl)ethyl]-1,3-thiazolidine-2,4-dione
• 中文别名: 5-(4-(2-(5-乙基吡啶-2-基)乙氧基)苄基)-3-(2-(5-乙基吡啶-2-基)乙基)噻唑烷-2,4-二酮 (匹格列酮杂质); 吡格列酮欧洲药典杂质C; 吡格列酮05 C; 吡格列酮杂质; 吡格列酮05; 吡格列酮杂质BG-C; 吡格列酮杂质03; N-乙基(2 - 吡啶基-5-乙基)吡格列酮; 吡格列酮杂质C; 吡格列酮05 游离; 吡格列酮杂质3(吡格列酮杂质C); 5-[4-[2-(5-乙基吡啶-2-基)乙氧基]苄基]-3-[2-(5-乙基吡啶-2-基)乙基]噻唑烷-2,4-二酮; 盐酸吡格列酮杂质C; 匹格列酮杂质C; N-乙基(2-吡啶基-5-乙基)吡格列酮; 盐酸吡咯列酮杂质C 标准品
• 英文别名: Pioglitazone Impurity; N-[Ethyl-(2-pyridyl-5-ethyl) pioglitazone; (5RS)-5-[[4-[2-(5-Ethylpyridin-2-yl; Pioglitazone Impurity 3(Pioglitazone Impurity C); UNII-0A40W8CWPF; Pioglitazone Hydrochloride Impurity C; Pioglitazone Impurity C/ Pioglitazone Related Compound C (N-Alkyl Pioglitazone); N-(Ethyl-(2-pyridyl-5-ethyl)) pioglitazone; Pioglitazone hydrochloride impurity,N-alkylpioglitazone-[USP]; Pioglitazone Impurity 3; BGLT-05; 5-{4-[2-(5-Ethyl-pyridin-2-yl)-ethoxy]-benzylidene}-3-[2-(5-ethyl-pyridin-2-yl)-ethyl]-thiazolidine-2,4-dione; N-Alkyl Pioglitazone; Pioglitazone impurity C Pioglitazone RC C; 5-{4-[2-(5-ethyl-pyridin-2-yl)ethoxy]benzyl}-3-[2-(5-ethyl-pyridin-2-yl)ethyl]-1,3-thiazolidine-2,4-dione; (5RS)-5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]- phenyl]methyl]-3-[2-(5-ethylpyridin-2-yl)- ethyl]thiazolidine-2,4-dione; 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-N-[2-(5-ethylpyridin-2-yl)ethyl]-2,4-thiazolidinedione; (+/-)-5-(4-(2-(5-Ethylpyridin-2-yl)ethoxy)benzyl)-3-(2-(5-ethylpyridin-2-yl)ethyl)thiazolidine-2,4-dione; 5-[4-[2-(5-Ethylpyridin-2-yl)ethoxy]benzyl]-3-[2-(5-ethylpyridin-2-yl)ethyl]thiazolidine-2,4-dione; (5RS)-5-[[4-[2-(5-Ethylpyridin-2-yl)ethoxy]phenyl]methyl]-3-[2-(5-ethylpyridin-2-yl)ethyl]thiazolidi; Pioglitazone hydrochloride specified impurity C [EP]; N-[Ethyl-(2-pyridyl-5-ethyl) Pioglitazone(Pioglitazone Impurity); 2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-3-[2-(5-ethyl-2-pyridinyl)ethyl]; Pioglitazone IMpurity C; Pioglitazone impurities1588; 5-(4-(2-(5-Ethylpyridin-2-yl)ethoxy)benzyl)-3-(2-(5-ethylpyridin-2-yl)ethyl)thiazolidine-2,4-dione (Pioglitazone Impurity)

物化性质

• 密度: 1.217g/cm3
• 沸点: 663.3ºC at 760 mmHg
• 熔点: 93 ºC
• 分子式: C₂₈H₃₁N₃O₃S
• 分子量: 489.62900
• 闪点: 354.9ºC
• 精确质量: 489.20900
• PSA: 97.69000
• LogP: 5.01000
• 折射率: 1.612

合成路线

105355-27-9 144809-27-8 ~51% 952188-00-0 16106-44-8

文献：Richter, Jindrich; Jirman; Havlicek; Hrdina Pharmazie, 2007 , vol. 62, # 8 p. 580 - 584

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