247068-82-2

• 常用中文名：卡非佐米中间体
• 常用英文名：[(1S)-3-Methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]carbamic acid 1,1-dimethylethyl ester
• CAS号：247068-82-2
• 分子式：C₁₄H₂₅NO₄
• 分子量：271.353
• 发布时间：2018-02-16 08:00:00
• 更新时间：2026-07-01 16:09:19

名称

• 中文名: 卡非佐米中间体
• 英文名: tert-butyl N-[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]carbamate
• 中文别名: 卡非佐米中间体B; PR171关键中间体1; N-[(2S)-4-甲基-1-[(2R)-2-甲基环氧乙烷-2-基]-1-氧代-2-戊基]氨基甲酸叔丁酯; PR171中间体(BOC保护); 叔-丁基 ((S)-4-甲基-1-((R)-2-甲基噁丙环-2-基)-1-氧亚基戊烷-2-基)氨基甲酯; 卡菲佐米中间体; 卡非佐米/卡菲佐咪中间体[(1S)-3-甲基-1-[[(2R)-2-甲基环氧乙基]羰基]丁基]氨基甲酸叔丁酯; [(1S)-3-甲基-1-[[(2R)-2-甲基环氧乙烷基]羰基]丁基]氨基甲酸叔丁酯; 卡非佐米环氧中间体(BOC保护); 卡菲佐米S构型; 卡菲佐咪中间体,PR171中间体; N-[(2S)-4-甲基-1-[(2R)-2-甲基环氧乙烷-2-基]-1-氧代-2-戊基]氨基甲酸叔丁酯/247-2; BOC-保护卡菲佐咪中间体,[(1S)-3-甲基-1-[[(2R)-2-甲基环氧乙基]羰基]丁基]氨基甲酸叔丁酯; BOC(三元环); 叔-丁基 N-[(2S)-4-甲基-1-[(2R)-2-甲基噁丙环-2-基]-1-氧亚基戊烷-2-基]氨基甲酯; [(1S)-3-甲基-1-[[(2R)-2-甲基环氧乙基]羰基]丁基]氨基甲酸叔丁酯; 叔丁基 ((S)-4-甲基-1-((R)-2-甲基环氧乙烷-2-基)-1-氧代戊-2-基)氨基甲酸酯; PR171中间体; PR171关键中间体I; 叔丁基((S)-4-甲基-1-((R)-2 -甲基环氧乙烷-2-基)-1-氧代戊-2-基)氨基甲酸叔丁酯; 卡非左米杂质11; (S)-2-(Boc-氨基)-4-甲基-1-[(R)-2-甲基环氧乙烷-2-基]-1-戊酮; 卡非佐米(CFILZOMIB)中间体; 原料药卡非佐米关键中间体(PR171中间体); 卡菲佐咪中间体
• 英文别名: CbaMic acid,N-[ (1S)-3-Methyl-1-[[(2R)-2-Methyl-2-oxira-nyl]cbony1] -, 1,1-diMethyl ethy1 ester; tert-butyl N-[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]cbamate; N-[(1S)-3-Methyl-1-[[(2R)-2-Methyl-2-oxiranyl]carbonyl]butyl]-, 1,1-diMethylethyl ester; Boc-LeuEK(tert-butyl (S)-4-Methyl-1-((R)-2-Methyloxiran-2-yl)-1-oxopentan-2-ylcbaMate ); Boc-L-leucine epoxyketone; ert-Butyl ((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopen; CbaMic acid, N-[(1S)-3-Methyl-1-[[(2R)-2-Methyl-2-oxiranyl]carbonyl]butyl]-, 1,1-diMethylethyl ester; 2-Methyl-2-propanyl {(2S)-4-methyl-1-[(2R)-2-methyl-2-oxiranyl]-1-oxo-2-pentanyl}carbamate; PR171 intermedaite I; Boc-L-leucine oxyketone; N-[(1S)-3-Methyl-1-[[(2R)-2-Methyl-2-oxiranyl]carbonyl]butyl]-CbaMic acid, 1,1-diMethylethyl ester; ert-butylN-[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]cbamate; (S)-2-(Boc-amino)-4-methyl-1-[(R)-2-methyloxiran-2-yl]-1-pentanone; CfilzomibIntermediateB; Carbamic acid, N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-, 1,1-dimethylethyl ester; tert-butyl 4-methyl-1-(2-methyloxiran-2-yl)-1-oxopentan-2-ylcbamate; EOS-60549; [(1S)-3-Methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]cbamic acid 1,1-dimethylethyl ester; N-Boc-2(S)-Amino-4-methyl-1-[(2R)-methyl-oxiranyl]-pentan-1-one; Boc-leucine-epoxyketone; ((1S)-3-METHYL-1-(((2R)-2-METHYLOXRANYL)carbonyl)BUTYL)CBAMIC ACID 1,1-DIMETHYLETHYL ESTER; tert-butyl (S)-4-Methyl-1-((R)-2-Methyloxiran-2-yl)-1-oxopentan-2-ylcbaMate; Boc-leucine-oxyketone; [(1S)-3-Methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]cb; [(1S)-3-Methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]cbamic; CFE-4B (Cfilzomib); (2S)-2-(Boc-amino)-4-Methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentane ee

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 369.8±37.0 °C at 760 mmHg
• 分子式: C₁₄H₂₅NO₄
• 分子量: 271.353
• 闪点: 177.5±26.5 °C
• 精确质量: 271.178345
• PSA: 71.42000
• LogP: 2.87
• 蒸汽压: 0.0±0.8 mmHg at 25°C
• 折射率: 1.472
• 储存条件: 2-8°C，干燥密封

合成路线

247068-81-1 ~25% 247068-82-2

文献：CREIGHTON UNIVERSITY; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; MURRAY, Thomas F.; GERWICK, William H.; PEREIRA-BADILLA, Alban R.; KALE, Andrew; BYRUM, Tara; DEBONSI, Hosana; MOORE, Bradley S.; GILSON, Michael Kenneth; FENLEY, Andrew Patent: WO2013/9923 A1, 2013 ; Location in patent: Sheet 4; 5 ;

87694-50-6 ~% 247068-82-2

文献：CREIGHTON UNIVERSITY; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; MURRAY, Thomas F.; GERWICK, William H.; PEREIRA-BADILLA, Alban R.; KALE, Andrew; BYRUM, Tara; DEBONSI, Hosana; MOORE, Bradley S.; GILSON, Michael Kenneth; FENLEY, Andrew Patent: WO2013/9923 A1, 2013 ;

13139-15-6 ~% 247068-82-2

文献：CENTRAX INTERNATIONAL, INC.; FAN, Xiaoqing, Michelle; CEN, Jian, James Patent: WO2014/18807 A1, 2014 ;

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