144485-80-3

• 常用中文名：7-chloro-2-ethyl-3-(3-methyl-1,2-oxazol-5-yl)quinazolin-4-one
• 常用英文名：7-chloro-2-ethyl-3-(3-methyl-1,2-oxazol-5-yl)quinazolin-4-one
• CAS号：144485-80-3
• 分子式：C₁₄H₁₂ClN₃O₂
• 分子量：289.71700
• 发布时间：2016-09-08 04:25:15
• 更新时间：2024-01-31 19:28:02

名称

• 英文名: 7-chloro-2-ethyl-3-(3-methyl-1,2-oxazol-5-yl)quinazolin-4-one

物化性质

• 密度: 1.41g/cm3
• 沸点: 493.6ºC at 760 mmHg
• 分子式: C₁₄H₁₂ClN₃O₂
• 分子量: 289.71700
• 闪点: 252.3ºC
• 精确质量: 289.06200
• PSA: 60.92000
• LogP: 2.89790
• 蒸汽压: 6.96E-10mmHg at 25°C
• 折射率: 1.667

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : VA2492020 CHEMICAL NAME : 4(3H)-Quinazolinone, 7-chloro-2-ethyl-3-(3-methyl-5-isoxazolyl)- CAS REGISTRY NUMBER : 144485-80-3 LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C14-H12-Cl-N3-O2 MOLECULAR WEIGHT : 289.74 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression REFERENCE : FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >500 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory depression REFERENCE : FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989- Volume(issue)/page/year: 47,465,1992

合成路线

41995-04-4 ~% 144485-80-3

文献：Plescia; Diadone; Raffa; Bajardi; Caruso; Cutuli; Amico-Roxas Farmaco, 1992 , vol. 47, # 4 p. 465 - 475

144485-98-3 ~% 144485-80-3

文献：Plescia; Diadone; Raffa; Bajardi; Caruso; Cutuli; Amico-Roxas Farmaco, 1992 , vol. 47, # 4 p. 465 - 475

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