1416992-39-6

• 常用中文名：GC376
• 常用英文名：GC376
• CAS号：1416992-39-6
• 分子式：C₂₁H₃₀N₃NaO₈S
• 分子量：507.53
• 发布时间：2018-04-16 10:02:03
• 更新时间：2025-08-25 00:47:26
• GC376 is a novel, first-in-class, small molecule protease inhibitor with a favorable therapeutic index demonstrated in preclinical studies. A common feature of viruses in the picornavirus-like supercluster (including coronaviruses) is a 3C or 3C-like protease (3Cpro or 3CLpro, respectively) responsible for viral replication. Viruses in this family include human coronavirus 229E, transmissible gastroenteritis virus of swine (TGEV), murine hepatitis virus (MHV), bovine coronavirus (BCV), feline infectious peritonitis virus (FIPV), severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East Respiratory Syndrome (MERS) and COVID-19 (SARS-CoV-2). GC376 has been shown to be a potent inhibitor of this protease across all coronaviruses with a high therapeutic index.

名称

• 英文名: GC376

物化性质

• 分子式: C₂₁H₃₀N₃NaO₈S
• 分子量: 507.53
• 储存条件: -20°C，密闭，干燥
• 水溶解性: DMSO; In Vivo: GC376 is dissolved in 10% ethanol and 90% PEG-400.