154040-19-4

• 常用中文名：化合物：α-Synuclein (human)
• 常用英文名：α-Synuclein (61-95) (human) trifluoroacetate salt
• CAS号：154040-19-4
• 分子式：C₁₄₁H₂₃₅N₃₉O₄₉
• 分子量：3260.61
• 相关类别： 研究领域 神经疾病
• 发布时间：2018-07-04 15:16:21
• 更新时间：2026-07-04 11:12:58
• α-Synuclein (61-95) (human) 是 α-突触核蛋白 (α-Synuclein) 的疏水核心区域,可诱导神经元细胞死亡。α-Synuclein (61-95) (human) 可用于神经退行性疾病的研究,包括阿尔茨海默病 (AD) 和帕金森病 (PD)。

名称

• 中文名: 化合物：α-Synuclein (human)
• 英文名: NAC
• 中文别名: 化合物:α-Synuclein (human); 人α-突触核蛋白三氟乙酸盐/NAC,人α-突触核蛋白; Α-突触核蛋白Α-SYNUCLEIN (HUMAN)
• 英文别名: NAC //BP; L-Valine, L-α-glutamyl-L-glutaminyl-L-valyl-L-threonyl-L-aspaginyl-L-valylglycylglycyl-L-alanyl-L-valyl-L-valyl-L-threonylglycyl-L-valyl-L-threonyl-L-alanyl-L-valyl-L-alanyl-L-glutaminyl-L-lysyl-L-threonyl-L-valyl-L-α-glutamylglycyl-L-alanylglycyl-L-seryl-L-isoleucyl-L-alanyl-L-alanyl-L-alanyl-L-t; α-Synuclein (human) trifluoroacetate salt; NON-BETA-AMYLOID COMPONENT OF ALZHEIMER'S DISEASE (NAC); α-Synuclein (human); Non-Aβ Component of Alzheimer's Disease Amyloid; H-GLU-GLN-VAL-THR-ASN-VAL-GLY-GLY-ALA-VAL-VAL-THR-GLY-VAL-THR-ALA-VAL-ALA-GLN-LYS-THR-VAL-GLU-GLY-ALA-GLY-SER-ILE-ILE-ALA-ALA-ALA-THR-GLY-PHE-VAL-OH; Non-beta-Amyloid Component of Alzheimer’s Dise; L-Valine, L-α-glutamyl-L-glutaminyl-L-valyl-L-threonyl-L-aspaginyl-L-valylglycylglycyl-L-alanyl-L-valyl-L-valyl-L-threonylglycyl-L-valyl-L-threonyl-L-alanyl-L-valyl-L-alanyl-L-glutaminyl-L-lysyl-L-threonyl-L-valyl-L-α-glutamylglycyl-L-alanylglycyl-L-seryl-L-isoleucyl-L-alanyl-L-alanyl-L-alanyl-L-threonylglycyl-L-phenylalanyl; EQVTNVGGAVVTGVTAVAQKTVEGAGSIIAAATGFV; GLU-GLN-VAL-THR-ASN-VAL-GLY-GLY-ALA-VAL-VAL-THR-GLY-VAL-THR-ALA-VAL-ALA-GLN-LYS-THR-VAL-GLU-GLY-ALA-GLY-SER-ILE-ALA-ALA-ALA-THR-GLY-PHE-VAL; α-Synuclein (human) trifluoroacetate salt/NAC, α-Synuclein (human); amyloid protein non-aβ component; NON-A-BETA COMPONENT OF ALZHEIMER'S DISEASE AMYLOID; H-GLU-GLN-VAL-THR-ASN-VAL-GLY-GLY-ALA-VAL-VAL-THR-GLY-VAL-THR-ALA-VAL-ALA-GLN-LYS-THR-VAL-GLU-GLY-ALA-GLY-SER-ILE-ALA-ALA-ALA-THR-GLY-PHE-VAL-OH; AMYLOID PROTEIN NON-A BETA COMPONENT; NON-AB COMPONENT OF ALZHEIMER'S DISEASE AMYLOID; α-Synuclein(human); Non-Aβ CoMponent of AlzheiMer's Disease AMyloid NAC; NON-BETA-AMYLOID COMPONENT OF ALZHEIMER'S DISEASE; Amyloid Protein Non-Abeta Component >= (HPLC)

物化性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 2937.7±65.0 °C at 760 mmHg
• 分子式: C₁₄₁H₂₃₅N₃₉O₄₉
• 分子量: 3260.61
• 闪点: 1730.4±34.3 °C
• 精确质量: 3258.709473
• LogP: -6.81
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.553
• 储存条件: −20°C

生物活性

• 描述: α-Synuclein (61-95) (human) 是 α-突触核蛋白 (α-Synuclein) 的疏水核心区域,可诱导神经元细胞死亡。α-Synuclein (61-95) (human) 可用于神经退行性疾病的研究,包括阿尔茨海默病 (AD) 和帕金森病 (PD)。
• 相关类别:
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Tabner BJ, et al. Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease. Free Radic Biol Med. 2002 Jun 1;32(11):1076-83.

  [2]. Emadi S, et al. Inhibiting aggregation of alpha-synuclein with human single chain antibody fragments. Biochemistry. 2004 Mar 16;43(10):2871-8.

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3