2254605-76-8

• 常用中文名：MD001
• 常用英文名：MD001
• CAS号：2254605-76-8
• 分子式：C₂₅H₁₈O₅
• 分子量：398.407
• 发布时间：2021-01-09 18:22:16
• 更新时间：2025-08-25 21:52:43
• MD001 is a dual agonist of peroxisome proliferator-activated receptor α (PPARα) and PPARγ. It binds to PPARα and PPARγ but does not bind to PPARβ/δ. It increases transcriptional activity of PPARα and PPARγ and glucose consumption. MD001 decreases levels of glucose, insulin, free fatty acids, triglycerides, LDL, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) in blood and reduces the size and number of hepatic lipid droplets in diabetic db/db mice.

名称

• 英文名: MD001
• 英文别名: MD001; 5,7-Dihydroxy-8-methyl-4-phenyl-3-[(2E)-3-phenyl-2-propenoyl]-2H-chromen-2-one

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 575.1±45.0 °C at 760 mmHg
• 分子式: C₂₅H₁₈O₅
• 分子量: 398.407
• 闪点: 199.1±22.2 °C
• 精确质量: 398.115417
• LogP: 6.14
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.704