12705-41-8

12705-41-8结构式

英文名	{[(3S)-4-{[(3S,6S,9S,12S,15R,18S,21S)-3-[(1R)-1-Hydroxyethyl]-12,15-diisobutyl-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris{2-[(sulfomethyl)amino]ethyl}-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]amino}-3-{[(2S,3R)-3-hydroxy-2-({(2S)-2-[(6-methylheptanoyl)amino]-4-[(sulfomethyl)amino]butanoyl}amino)butanoyl]amino}-4-oxobutyl]amino}methanesulfonic acid
英文别名	{[(3S)-4-{[(3S,6S,9S,12S,15R,18S,21S)-3-[(1R)-1-Hydroxyethyl]-12,15-diisobutyl-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris{2-[(sulfomethyl)amino]ethyl}-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]amino}-3-{[(2S,3R)-3-hydroxy-2-({(2S)-2-[(6-methylheptanoyl)amino]-4-[(sulfomethyl)amino]butanoyl}amino)butanoyl]amino}-4-oxobutyl]amino}methanesulfonic acid 2,6,9,14-Tetraazapentadecane-1,15-disulfonic acid, 8-[(1R)-1-hydroxyethyl]-5-[[[(3S,6S,9S,12S,15R,18S,21S)-3-[(1R)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris[2-[(sulfomethyl)amino]ethyl]-1,4,7,10,13,16,19-heptaazacyclotricos-21-yl]amino]carbonyl]-11-[(6-methyl-1-oxoheptyl)amino]-7,10-dioxo-, (5S,8S,11S)-

描述	大肠杆菌素是一种对肾小管细胞具有细胞毒性的多粘菌素。大肠杆菌肽在体内的活性很差。大肠杆菌对6株铜绿假单胞菌表现出可检测的活性[1][2]。
相关类别	研究领域 >> 其他信号通路 >> 其他 >> 其他
体外研究	大肠杆菌对肾小管细胞有细胞毒性[1]。
体内研究	大肠杆菌容易在体内引起肾毒性[1]。大肠杆菌(306 mg/kg；皮下注射; 单次剂量) 在小鼠体内对铜绿假单胞菌菌株 (i.p.)相对无效[2]。
参考文献	[1]. Zavascki AP, et al. Nephrotoxicity of Polymyxins: Is There Any Difference between Colistimethate and Polymyxin B? Antimicrob Agents Chemother. 2017 Feb 23;61(3):e02319-16. [2]. Davis SD. Activity of gentamicin, tobramycin, polymyxin B, and colistimethate in mouse protection tests with Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1975 Jul;8(1):50-3.