1828-12-2

• 常用中文名：1-(4-fluorophenyl)-3-(1-piperidyl)propan-1-one hydrochloride
• 常用英文名：1-(4-fluorophenyl)-3-(1-piperidyl)propan-1-one hydrochloride
• CAS号：1828-12-2
• 分子式：C₁₄H₁₉ClFNO
• 分子量：271.75800
• 发布时间：2017-04-18 09:15:21
• 更新时间：2024-01-12 01:19:45

名称

• 英文名: 1-(4-fluorophenyl)-3-piperidin-1-ylpropan-1-one,hydrochloride
• 英文别名: Propiophenone,4'-fluoro-3-piperidino-,hydrochloride; 4'-Fluoro-3-piperidinopropiophenone hydrochloride; CN HCl

物化性质

• 密度: 1.093g/cm3
• 沸点: 351.4ºC at 760 mmHg
• 分子式: C₁₄H₁₉ClFNO
• 分子量: 271.75800
• 闪点: 166.3ºC
• 精确质量: 271.11400
• PSA: 20.31000
• LogP: 3.62430
• 蒸汽压: 4.11E-05mmHg at 25°C
• 折射率: 1.521

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UH1830000 CHEMICAL NAME : Propiophenone, 4'-fluoro-3-piperidino-, hydrochloride CAS REGISTRY NUMBER : 1828-12-2 LAST UPDATED : 199112 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C14-H18-F-N-O.Cl-H MOLECULAR WEIGHT : 271.79 WISWESSER LINE NOTATION : T6NTJ A2VR DF &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 350 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,480,1970 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 13,480,1970

合成路线

50-00-0 6091-44-7 403-42-9 ~72% 1828-12-2

文献：Pathak; Singh Die Pharmazie, 1980 , vol. 35, # 7 p. 434 - 434

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