2179-16-0

• 常用中文名：L-Glutamic acid,N-[4-[[1-(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)ethyl]amino]benzoyl]-
• 常用英文名：L-Glutamic acid,N-[4-[[1-(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)ethyl]amino]benzoyl]-
• CAS号：2179-16-0
• 分子式：C₂₀H₂₁N₇O₆
• 分子量：455.42400
• 相关类别： 研究领域 其他
• 发布时间：2017-09-16 15:52:10
• 更新时间：2024-04-01 18:54:40
• Ninopterin (9-Me-PGA; 9-Methyl PGA) 是一种叶酸类似物。

名称

• 英文名: L-Glutamic acid, 9-methylpteroyl
• 英文别名: Bremfol; ninopterin; 9-Methyl-PGA; Folic acid,9-methyl; 9-Methyl pteroylglutamic acid; 9-Me-pga

物化性质

• 密度: 1.64g/cm3
• 分子式: C₂₀H₂₁N₇O₆
• 分子量: 455.42400
• 精确质量: 455.15500
• PSA: 213.54000
• LogP: 1.97360
• 折射率: 1.746
• 储存条件: 库房通风低温干燥

生物活性

• 描述: Ninopterin (9-Me-PGA; 9-Methyl PGA) 是一种叶酸类似物。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. K P Chepenik, Effects of transitory maternal pteroylglutamic acid (PGA) deficiency on respiratory control ratios, phosphorylative capacity, and cytochrome oxidase activities of mitochondria from rat embryos. Teratology (Report missing IFs). 1972 Apr;5(2):191-8.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : MA0602000 CHEMICAL NAME : Glutamic acid, N-(p-((1-(2-amino-4-hydroxy-6-pteridinyl)ethyl)amino) benzoyl)- L- CAS REGISTRY NUMBER : 2179-16-0 BEILSTEIN REFERENCE NO. : 0069787 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C20-H21-N7-O6 MOLECULAR WEIGHT : 455.48 WISWESSER LINE NOTATION : T6MTJ BZ DQ F2MR DVMYVQ2VQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 20 mg/kg SEX/DURATION : female 10-12 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 1,375,1968 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 405 mg/kg SEX/DURATION : female 11-14 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - other effects to embryo REFERENCE : BNEOBV Biology of the Neonate. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.15- 1970- Volume(issue)/page/year: 41,52,1982 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 400 mg/kg SEX/DURATION : female 11-14 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : JEEMAF Journal of Embryology and Experimental Morphology. (Essex, UK) V.1-98, 1953-86. For Publisher information, see DEVPED Volume(issue)/page/year: 41,289,1977

合成路线

1004-75-7 4271-30-1 ~% 2179-16-0

文献：Hultquist et al. Journal of the American Chemical Society, 1949 , vol. 71, p. 619,621.

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