1246815-57-5

• 常用中文名：培拉嗪-d8 二盐酸盐
• 常用英文名：Perazine-d8 dihydrochloride salt
• CAS号：1246815-57-5
• 分子式：C₂₀H₁₉D₈Cl₂N₃S
• 分子量：420.47
• 发布时间：2022-03-28 17:22:40
• 更新时间：2024-01-06 18:15:33
• 培拉嗪-d8是氘化形式的培拉嗪，一种人细胞色素P450同工酶1A2（CYP1A2）抑制剂。在人肝微粒体和CYP1A2中的狄克逊分析表明，培拉嗪可以有效抑制咖啡因3-N-去甲基化和1-N-去甲基化，并适度抑制咖啡因7-N-去甲基化。超体CYP1A2对C-8-羟基化的抑制作用减弱，而咖啡因对C-8-羟基化的抑制作用较弱。 Perazine-d8 is a deuterated form of Perazine , a human cytochrome P450 isoenzyme 1A2 (CYP1A2) inhibitor. Dixon analysis in human liver microsomes and Supersomes CYP1A2 showed Perazine acts as a potent inhibitor of caffeine 3-N-demethylation and 1-N-demethylation, as well as moderate inhibition of caffeine 7-N-demethylation. Attenuation of C-8-hydroxylation was seen in Supersomes CYP1A2, however, weak inhibition of caffeine C-8-hydroxylation was found.

名称

• 中文名: 培拉嗪-d8
• 英文名: Perazine-d8
• 英文别名: Perazine-d8 Dihydrochloride Salt; 10-{3-[4-Methyl(2H8)-1-piperazinyl]propyl}-10H-phenothiazine; 10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl-2,2,3,3,5,5,6,6-d8)propyl]-

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 493.6±40.0 °C at 760 mmHg
• 熔点: 191-199° C (dec.)
• 分子式: C₂₀H₁₉D₈Cl₂N₃S
• 分子量: 420.47
• 闪点: 252.3±27.3 °C
• 精确质量: 347.227142
• LogP: 4.04
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.616
• 储存条件: -20°C储存