6742-07-0

• 常用中文名：1-β-d-ARABINOFURANOSYL-2′,3′,5′-TRIACETATE
• 常用英文名：1-β-d-ARABINOFURANOSYL-2′,3′,5′-TRIACETATE
• CAS号：6742-07-0
• 分子式：C₁₅H₁₉N₃O₈
• 分子量：369.32700
• 发布时间：2017-06-02 12:47:12
• 更新时间：2024-01-09 21:06:22

名称

• 英文名: [3,4-diacetyloxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl acetate
• 英文别名: triacetylcytarabine; 2',3',5'-tri-O-acetyl-arabinofuranosyl-cytidine; AraC 2',3',5'-tri-O-acetyl ester

物化性质

• 密度: 1.52g/cm3
• 沸点: 507.4ºC at 760 mmHg
• 分子式: C₁₅H₁₉N₃O₈
• 分子量: 369.32700
• 闪点: 260.6ºC
• 精确质量: 369.11700
• PSA: 149.04000
• 折射率: 1.61

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : HA5600000 CHEMICAL NAME : Cytosine, 1-beta-D-arabino-furanosyl-, 2',3',5'-triacetate CAS REGISTRY NUMBER : 6742-07-0 LAST UPDATED : 199606 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C15-H19-N3-O8 MOLECULAR WEIGHT : 369.37 WISWESSER LINE NOTATION : T6NVNJ DZ A- BT5OTJ COV1 DOV1 E1OV1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5010 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4400 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 680 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 gm/kg/5D-I TOXIC EFFECTS : Related to Chronic Data - death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 750 mg/kg/15D-I TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea Blood - changes in bone marrow (not otherwise specified) Nutritional and Gross Metabolic - body temperature increase TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 3 gm/kg/15D-I TOXIC EFFECTS : Kidney, Ureter, Bladder - changes primarily in glomeruli Blood - thrombocytopenia Related to Chronic Data - death TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Primate - monkey DOSE/DURATION : 750 mg/kg/15D-I TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death MUTATION DATA TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Leukocyte DOSE/DURATION : 49 umol/L REFERENCE : CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 49,2551,1984

合成路线

25130-27-2 ~90% 6742-07-0

文献：Saladino, Raffaele; Mincione, Enrico; Crestini, Claudia; Mezzetti, Maurizio Tetrahedron, 1996 , vol. 52, # 19 p. 6759 - 6780

6742-08-1 ~% 6742-07-0

文献：Bobek; Kavai; Sharma; Grill; Dutschman; Cheng Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 2154 - 2157

69-74-9 ~% 6742-07-0

文献：Bobek; Kavai; Sharma; Grill; Dutschman; Cheng Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 2154 - 2157

82855-62-7 ~% 6742-07-0

文献：Divakar, K.J.; Reese, Colin B. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1171 - 1176

3736-77-4 ~% 6742-07-0

文献：Divakar, K.J.; Reese, Colin B. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1171 - 1176

3083-77-0 ~% 6742-07-0

文献：Divakar, K.J.; Reese, Colin B. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1171 - 1176

58-96-8 ~% 6742-07-0

文献：Divakar, K.J.; Reese, Colin B. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1171 - 1176

14057-18-2 ~% 6742-07-0

文献：Divakar, K.J.; Reese, Colin B. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1171 - 1176

880633-88-5 ~% 6742-07-0

文献：ANGIOGENE PHARMACEUTICALS LIMITED; THE GRAY LABORATORY CANCER RESEARCH TRUST Patent: WO2006/32921 A1, 2006 ; Location in patent: Page/Page column 25 ;

上下游产品

上游产品  9
25130-27-2 6742-08-1 69-74-9 82855-62-7
3736-77-4 3083-77-0 58-96-8 14057-18-2
880633-88-5
下游产品  1
147-94-4