86436-45-5

• 常用中文名：N-(Phenoxyacetyl)deacetylcolchicine
• 常用英文名：N-(Phenoxyacetyl)deacetylcolchicine
• CAS号：86436-45-5
• 分子式：C₂₈H₂₉NO₇
• 分子量：491.53200
• 发布时间：2017-05-30 21:20:11
• 更新时间：2024-02-03 11:42:19

名称

• 英文名: 2-phenoxy-N-(1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide
• 英文别名: 2-Phenoxy-N-(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide; N-(Phenoxyacetyl)deacetylcolchicine; Acetamide,2-phenoxy-N-(5,6,7,9-tetrahydro-9-oxo-1,2,3,10-tetramethoxybenzo(a)heptalen-7-yl)-,(S)

物化性质

• 密度: 1.28g/cm3
• 沸点: 807.8ºC at 760 mmHg
• 分子式: C₂₈H₂₉NO₇
• 分子量: 491.53200
• 闪点: 442.3ºC
• 精确质量: 491.19400
• PSA: 92.32000
• LogP: 4.32160
• 折射率: 1.612

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : AC7670000 CHEMICAL NAME : Acetamide, 2-phenoxy-N-(5,6,7,9-tetrahydro-9-oxo-1,2,3,10-tetram ethoxybenzo(a)heptale n- 7-yl)-, (S)- CAS REGISTRY NUMBER : 86436-45-5 LAST UPDATED : 199612 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C28-H29-N-O7 MOLECULAR WEIGHT : 491.58 WISWESSER LINE NOTATION : T B677 MV&T&J CO1 DO1 EO1 JMV1OR& NO1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,1365,1983

合成路线

14316-61-1 3476-50-4 ~% 86436-45-5

文献：Brossi; Sharma; Atwell; Jacobson; Iorio; Molinari; Chignell Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1365 - 1369

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