95058-92-7

• 常用中文名：(3R,S)-2,2-二氟-3-羟基-(2,2-二甲基二氧环戊-4-基)丙酸乙酯
• 常用英文名：Ethyl (3R,S)-2,2-difluoro-3-hydroxy-3-(2,2-dimethyldioxolan-4-yl)propionate
• CAS号：95058-92-7
• 分子式：C₁₀H₁₆F₂O₅
• 分子量：254.228
• 发布时间：2019-01-01 11:37:58
• 更新时间：2024-01-11 06:46:55

名称

• 中文名: 二氟-羟基-(亚异丙基二氧丙基)-丙酸乙酯
• 英文名: Ethyl (3R,S)-2,2-difluoro-3-hydroxy-3-(2,2-dimethyldioxolan-4-yl)propionate
• 中文别名: (3R,S)-2,2-二氟-3-羟基-(2,2-二甲基二氧环戊-4-基)丙酸乙酯; 吉西他滨中间体T3; (3R,S)-2,2-二氟-3-羟基-3-(2,2-二甲基二氧环戊-4-基)丙酸乙酯; 乙基-3-(2,2-二甲基-1,3-二氧戊烷-4-基)-2,2-二氟-3-羟基丙酸; (R)-3-((R)-2,2-二甲基-1,3-二氧五环-4-基)-2,2-二氟-3-羟基-丙酸乙酯
• 英文别名: ethyl 2-deoxy-2,2-difluoro-D-erythro,D-threo-pentonate; ethyl (3R,4R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-difluoro-3-hydroxypropanoate; Ethyl(3R,S)-2,2-difluoro-3-hydroxy-3-(2,2-dimethyldioxolan-4-yl)propionate; ethyl 2,2-difluoro-3-hydroxy-3-(2,2-dimethyl-[1,3]dioxolan-4-yl)propionate; 2-DEOXY-2,2-DIFLUORO-4,5-O-(1-METHYLETHYLIDENE)-D-ERYTHROPENTONIC ACID ETHYL ESTER; ethyl (D-erythro)-3-(hydroxy)-2,2-difluoro-3-(2,2-dimethyldioxalane-4-yl)propionate; (R)-ethyl 3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-difluoro-3-hydroxypropanoate; Pentonicacid, 2-deoxy-2,2-difluoro-4,5-O-(1-methylethylidene)-ethylester; Pentonic acid,2-deoxy-2,2-difluoro-4,5-O; D-erythro-Pentonic acid,2-deoxy-2,2-difluoro-4,5-O-(1-methylethylidene)-,ethyl ester (9CI); 2-Deoxy-2,2-Difluoro-4,5-o-(1-Methylethylidene) Pentonic Acid Ethyl Ester; Ethyl(3RS)-2,2-Difluoro-3-(2,2-Dimethylioxolan-4-yl)Propionate; ethyl (R)-2,2-difluoro-3-hydroxy-3-((R)-2,2-dimethyl-[1,3]dioxoran-4-yl)propionate; D-ERYTHRO-PENTONIC ACID,2-DEOXY-2,2-DIFLUORO-4,5-O-(1-METHYLETHYLIDENE)-,ETHYL ESTER; ethyl 2,2-difluoro-3-hydroxy-3-(2,2-dimethyl-dioxolan-4-yl)propionate; 2-Deoxy-2,2-difluoro-4,5-O-isopropylidene-D-erythro-pentonic Acid Ethyl Ester; Ethyl 3-(2,2-diMethyl-1,3-dioxolan-4-yl)-2,2-difluoro-3-hydroxypropanoate; (erytro) ethyl-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-difluoro-3-hydroxy propionate; ethyl (3R)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-difluoro-3-hydroxypropanoate; (1-methylethylidene)-,ethylester; propionate (T3); Pentonic acid, 2-deoxy-2,2-difluoro-4,5-O-(1-methylethylidene)-, ethyl ester; ethyl 2,2-difluoro-3(R)-hydroxy-3-((R)-2,2-dimethyldioxolan-4-yl)propionate; Ethyl 2-deoxy-2,2-difluoro-4,5-O-isopropylidenepentonate; 3-(2,2-Dimethyl[1,3]dioxolan-4-yl)-2,2-difluora-3-hydroxy-propionic acid ethyl ester; Ethyl(3RS)-2,2-Difluoro-3-(2,2-dimethyldioxolan-4-yl)propionate

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 338.4±37.0 °C at 760 mmHg
• 分子式: C₁₀H₁₆F₂O₅
• 分子量: 254.228
• 闪点: 158.5±26.5 °C
• 精确质量: 254.096573
• PSA: 64.99000
• LogP: 1.86
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.428

安全

• 海关编码: 2942000000

合成路线

667-27-6 15186-48-8 ~75% 95058-92-7

文献：PHARMAESSENTIA CORP. Patent: WO2006/119347 A1, 2006 ; Location in patent: Page/Page column 9-10 ;

942296-13-1 ~98% 151900-33-3 95058-92-7

文献：CHEMAGIS LTD.; PERRIGO COMPANY Patent: WO2007/70804 A2, 2007 ; Location in patent: Page/Page column 24-25 ;

上下游产品

上游产品  2
667-27-6 15186-48-8
下游产品  1
143234-90-6

海关

海关编码	2932999099
中文概述	2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%