CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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AY4390000
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CHEMICAL NAME :
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Alanine, 3-(p-chlorophenyl)-
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CAS REGISTRY NUMBER :
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1991-78-2
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LAST UPDATED :
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199609
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DATA ITEMS CITED :
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11
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MOLECULAR FORMULA :
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C9-H10-Cl-N-O2
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MOLECULAR WEIGHT :
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199.65
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WISWESSER LINE NOTATION :
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QVYZ1R DG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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7200 mg/kg/6W-I
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - changes in pulmonary vascular resistance
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REFERENCE :
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ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 22,2096,1972 ** REPRODUCTIVE DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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1896 mg/kg
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SEX/DURATION :
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female 15-20 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Maternal Effects - postpartum Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord)
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REFERENCE :
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BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 11,280,1974
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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2528 mg/kg
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SEX/DURATION :
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female 2-21 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - respiratory system Reproductive - Effects on Newborn - live birth index (measured after birth)
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REFERENCE :
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BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 11,280,1974
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TYPE OF TEST :
-
TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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1896 mg/kg
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SEX/DURATION :
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female 15-20 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
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REFERENCE :
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BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 11,280,1974
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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3160 mg/kg
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SEX/DURATION :
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female 2-21 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
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REFERENCE :
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BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 11,280,1974
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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516 mg/kg
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SEX/DURATION :
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female 3 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Maternal Effects - menstrual cycle changes or disorders
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REFERENCE :
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JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 22,379,1970
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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300 mg/kg
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SEX/DURATION :
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female 18-21 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - biochemical and metabolic
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REFERENCE :
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FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 36,1034,1977
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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399 mg/kg
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SEX/DURATION :
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female 14-17 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Maternal Effects - postpartum
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REFERENCE :
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PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973- Volume(issue)/page/year: 8,263,1978
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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DOSE :
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500 mg/kg
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SEX/DURATION :
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male 5 day(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
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REFERENCE :
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JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 28,177,1972
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Parenteral
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DOSE :
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1100 mg/kg
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SEX/DURATION :
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female 8-16 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
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REFERENCE :
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TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 27,68A,1983
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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400 mg/kg
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SEX/DURATION :
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female 8 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
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REFERENCE :
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RJDBE2 Russian Journal of Developmental Biology. (Plenum Publishing, 233 Spring St., New York, NY 10013) V.23- 1992- Volume(issue)/page/year: 26,295,1995
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